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| Product Name | ZM447439 |
| Description |
Aurora B kinase inhibitor |
| Purity | >98% (TLC); NMR (Conforms) |
| CAS No. | 331771-20-1 |
| Molecular Formula | C29H31N5O4 |
| Molecular Weight | 513.6 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | May be dissolved in DMSO (50mg/mL) |
| Source | Synthetic |
| Appearance | Orange solid |
| SMILES | COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)NC(=O)C4=CC=CC=C4)OCCCN5CCOCC5 |
| InChI | InChI=1S/C29H31N5O4/c1-36-26-18-24-25(19-27(26)38-15-5-12-34-13-16-37-17-14-34)30-20-31-28(24)32-22-8-10-23(11-9-22)33-29(35)21-6-3-2-4-7-21/h2-4,6-11,18-20H,5,12-17H2,1H3,(H,33,35)(H,30,31,32) |
| InChIKey | OGNYUTNQZVRGMN-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Cite This Product | ZM447439 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-489) |
Biological Description
| Alternative Names | ZM 447439, N-[4-[[6-Methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]benzamide |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 9914412 |
| Scientific Background | ZM447439 is a potent and selective inhibitor of Aurora B kinase. ZM447439 induces cell growth arrest mid-way through mitosis, and therefore effectively activates apoptosis. |
| References |
1. Walsby E., Walsh V., Pepper C., Burnett A., & Mills K. (2008) Haematologica. 93(5): 662–669. 2. Kim K.W., et al. (2007) Int. J. Rad.Oncol. Biol. Phy. 67(5): 1519–1525. |
Product Images
Chemical structure of ZM447439 (SIH-489), a Aurora B kinase inhibitor. CAS #: 331771-20-1. Molecular Formula: C29H31N5O4. Molecular Weight: 513.6 g/mol.
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