Alzheimer's Disease

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  • Alpha Synuclein Protein

    Human Recombinant Alpha Synuclein Pre-formed Fibrils (Type 2)

    Catalog No. SPR-317

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    Expression System E. coli
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    SPR-317_Alpha-Synuclein-Preformed-Fibrils-Protein-TEM-4.png
    TEM of Type 2 Alpha Synuclein Pre-formed Fibrils (PFFs) (SPR-317)Alpha Synuclein Pre-formed Fibrils (PFF), Type 1 (cat#SPR-322) and Type 2 (cat#SPR-317) do have small secondary structure differences.SDS-Page of Type 2 Human Recombinant Alpha Synuclein Protein Pre-formed Fibrils (SPR-317)Type 2 alpha synuclein Pre-formed fibrils (SPR-317) do not seed the formation of new alpha synuclein fibrils from the pool of alpha synuclein monomers (SPR-321) at the same rate as Type 1 alpha synuclein Pre-formed fibrils (SPR-322) as shown by lower fluorescence intensity values of Thioflavin T over time.Primary rat hippocampal neurons show lewy body inclusion formation when treated with Type 1 Alpha Synuclein Protein Pre-formed Fibrils (SPR-322) (D-F), but not when treated with Type 2 Alpha Synuclein Protein Pre-formed Fibrils (SPR-317) (A-C).Toxicity results comparing Active Human Recombinant Alpha Synuclein Pre-formed Fibrils (Type 2) and Active Human Recombinant Alpha Synuclein Pre-formed Fibrils (Type 1)LDH assay shows effect of alpha synuclein PFFs on mouse primary neuronsMTT assay effects of alpha synuclein PFFs on mouse primary neurons

  • Alpha Synuclein Protein

    Human Recombinant Alpha Synuclein Protein Monomers (Type 1)

    Catalog No. SPR-321

    5 out of 5 based on 1 customer rating
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    Expression System E. coli
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    SPR-321_Alpha-Synuclein-Protein-Monomer-Thioflavin-T-assay-1.png
    SDS-Page of huma alpha synuclein monomer (SPR-321)

  • Alpha Synuclein Protein

    Human Recombinant Alpha Synuclein Pre-formed Fibrils (Type 1)

    Catalog No. SPR-322

    5 out of 5 based on 1 customer rating
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    Expression System E. coli
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    SPR-322_Alpha-Synuclein-Protein-Preformed-Fibrils-Protein-TEM-7.png
    Αlpha Synuclein Oligomers Have Distinct Secondary Structure Differences Compared to Fibrils.Alpha Synuclein Pre-formed Fibrils (PFF), Type 1 (cat#SPR-322) and Type 2 (cat#SPR-317) do have small secondary structure differences.StressMarq’s Alpha Synuclein PFFs (red) cat#SPR-322, were shown to be taken up by SH-SY5Y cells and transmitted to neuronal iPSCs within 14 days.SDS-Page of Type 1 Human Recombinant Alpha Synuclein Protein Pre-formed Fibrils (SPR-322)Type 1 alpha synuclein Pre-formed Fibrils (SPR-322) seed the formation of new alpha synuclein fibrils from the pool of alpha synuclein monomers (SPR-321) as shown by increased fluorescence intensity by Thioflavin T over time.Immunocytochemistry/Immunofluorescence of Human Alpha Synuclein Protein Protein (SPR-322)Mouse neurocortical primary cells seeded with fluorescently-labelled alpha synuclein PFFsMouse neurocortical primary cells seeded with fluorescently-labelled alpha synuclein PFFs cause endogenous alpha synuclein phosphorylationTEM of Type 1 Alpha Synuclein Pre-formed Fibrils (PFFs) (SPR-322)IHC of Sprague-Dawley rat brain injected with Type 1 human alpha synuclein Pre-formed Fibrils (SPR-322)Primary rat hippocampal neurons show lewy body inclusion formation when treated with Type 1 Alpha Synuclein Protein Pre-formed Fibrils (SPR-322) (D-F), but not when treated with Type 2 Alpha Synuclein Protein Pre-formed Fibrils (SPR-317) (A-C).Toxicity results comparing Active Human Recombinant Alpha Synuclein Pre-formed Fibrils (Type 2) and Active Human Recombinant Alpha Synuclein Pre-formed Fibrils (Type 1)

  • Alpha Synuclein Protein

    Human Recombinant Alpha Synuclein Protein Monomers (Type 2)

    Catalog No. SPR-316

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    Expression System E. coli
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    SPR-316_Alpha-Synuclein-Protein-Monomer-Protein-SDS-Page-1.png
    Alpha Synuclein monomers (SPR-316) do not form new alpha synuclein fibrils when combined with Type 1 alpha synuclein Pre-formed fibrils (SPR-322) as shown by a limited increase in fluorescence intensity by Thioflavin T over time.Alpha Synuclein Monomer RT-QuiC AssayΑlpha Synuclein Oligomers Have Distinct Secondary Structure Differences Compared to Fibrils.Alpha Synuclein Pre-formed Fibrils (PFF), Type 1 (cat#SPR-322) and Type 2 (cat#SPR-317) do have small secondary structure differences.LDH assay shows effect of alpha synuclein monomers on mouse primary neuronsMTT assay shows effects of alpha synuclein monomers on mouse primary neurons

  • Doxorubicin Hydrochloride

    Apoptosis inducer

    Catalog No. SIH-390

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    CAS No. 25316-40-9
    Molecular Formula C27H29NO11•HCl
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    SIH-390_Doxorubicin_Hydrochloride_Chemical_Structure.png

  • Galanthamine HBr

    Acetylcholinesterase inhibitor

    Catalog No. SIH-530

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    CAS No. 1953-04-4
    Molecular Formula C17H22BrNO3
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    SIH-530-Galanthamine-HBr-Chemical-Structure.png

  • MOLECULAR SIGNATURE® Nitrotyrosine ELISA Kit

    Colorimetric detection of Nitrotyrosine

    Catalog No. SKT-126

    5 out of 5 based on 1 customer rating
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    Species Reactivity ALL
    Sample Types Cell lysates, Plasma, Serum, Urine
    SKU: SKT-126 Categories: ,

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    SKT-126_Nitrotyrosine_ELISA_Kit_Standard_Curve.png
    Diagram of the Competitive ELISA for the Nitrotyrosine ELISA Kit StressXpress - SKT-126Diagram of the Preparation of Nitrotyrosine Standards for the Nitrotyrosine ELISA Kit StressXpress - SKT-126Diagram of the Triplicate Sample Plate Format for the Nitrotyrosine ELISA Kit StressXpress - SKT-126

  • Pepstatin A

    Aspartic protease inhibitor

    Catalog No. SIH-533

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    CAS No. 26305-03-3
    Molecular Formula C34H63N5O9
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  • Stattic

    STAT3 inhibitor

    Catalog No. SIH-554

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    CAS No. 19983-44-9
    Molecular Formula C8H5NO4S
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    SIH-554-Stattic-Chemical-Structure.png

  • Trolox

    Antioxidant vitamin E derivative

    Catalog No. SIH-556

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    CAS No. 53188-07-1
    Molecular Formula C14H18O4
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    SIH-556-Trolox-Chemical-Structure.png

  • YM-01

    Hsp70 Inhibitor

    Catalog No. SIH-121

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    CAS No. 409086-68-6
    Molecular Formula C20H20ClN3OS2
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    SIH-121_YM-01_Chemical_Structure.png

  • YM-08

    Hsp70 Inhibitor

    Catalog No. SIH-122

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    CAS No. 812647-88-4
    Molecular Formula C19H17N3OS2
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    SIH-122_YM-08_Chemical_Structure.png

  • Z-VAD-FMK

    Pan-specific caspase inhibitor

    Catalog No. SIH-557

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    CAS No. 187389-52-2
    Molecular Formula C22H30FN3O7
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