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| Product Name | Fumonisin B1 |
| Description |
Ceramide synthase inhibitor |
| Purity | >98% |
| CAS No. | 116355-83-0 |
| Molecular Formula | C34H59NO15 |
| Molecular Weight | 721.83 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inducer |
| Solubility | Soluble to 10 mM in DMSO |
| Source | Synthetic |
| Appearance | Beige Solid |
| SMILES | CCCCC(C)C(C(CC(C)CC(CCCCC(CC(C(C)N)O)O)O)OC(=O)CC(CC(=O)O)C(=O)O)OC(=O)CC(CC(=O)O)C(=O)O |
| InChI | InChI=1S/C34H59NO15/c1-5-6-9-20(3)32(50-31(44)17-23(34(47)48)15-29(41)42)27(49-30(43)16-22(33(45)46)14-28(39)40)13-19(2)12-24(36)10-7-8-11-25(37)18-26(38)21(4)35/h19-27,32,36-38H,5-18,35H2,1-4H3,(H,3 |
| InChIKey | UVBUBMSSQKOIBE-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R20/21/22- Harmful by inhalation, in contact with skin and if swallowed R60- May impair fertility R61- May cause harm to the unborn child Hazard Phrases: H351 Precautionary Phrases: P281 |
| Cite This Product | Fumonisin B1 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-234) |
Biological Description
| Alternative Names | 2,2'-{(19-Amino-11,16,18-trihydroxy-5,9-dimethyl-6,7-icosanediyl)bis[oxy(2-oxo-2,1-ethanediyl)]}disuccinic acid |
| Research Areas | Apoptosis, Cancer |
| PubChem ID | 3431 |
| Scientific Background | Fumonisin B1 is the most prevalent member of a family of toxins. It is hepatotoxic and nephrotoxic in all animal species. It occupies the space and electrostatic interactions of both sphinganine and fatty acyl-CoA (1). Due to this mechanism of action, it has toxic effects in humans such as neural tube defects (2), esophageal cancer, acute mycotoxicosis, and various other carcinogenic effects. Another effect of exposure to FB1 is apoptosis (2). |
| References |
1. European commission (2007). “Fumonisin B1”. Opinion of the scientific committee on food on Fusarium toxins (27). 2. Stockmann-Juvalla H., and Savolainen K. (2008) Human and Exp. Toxicology. 27: 799-809. |
Product Images
Chemical structure of Fumonisin B1 (SIH-234), a Blocks sphingolipid biosynthesis. CAS #: 116355-83-0. Molecular Formula: C34H59NO15. Molecular Weight: 721.83 g/mol.
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