Necrostatin

Necroptosis inhibitor

Catalog No. SIH-213

5 out of 5 based on 1 customer rating
CAS No. 4311-88-0
Molecular Formula C13H13N3OS
SKU: SIH-213 Categories: ,

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SIH-213_Necrostatin_Chemical_Structure.png
Product Name Necrostatin
Description

Necroptosis inhibitor

Purity >98%
CAS No. 4311-88-0
Molecular Formula C13H13N3OS
Molecular Weight 259.33
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble to 15 mM in ethanol, and to 30 mM in DMSO
Source Synthetic
Appearance Light Yellow Solid
SMILES CN1C(=O)C(NC1=S)CC2=CNC3=CC=CC=C32
InChI InChI=1S/C13H13N3OS/c1-16-12(17)11(15-13(16)18)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,11,14H,6H2,1H3,(H,15,18)
InChIKey TXUWMXQFNYDOEZ-UHFFFAOYSA-N
Safety Phrases Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Cite This Product Necrostatin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-213)

Biological Description

Alternative Names 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone, Necrostatin-1
Research Areas Apoptosis, Cancer
PubChem ID 2828334
Scientific Background Necrostatin-1 is a specific inhibitor of necroptosis that reduces ischemic tissue damage in stroke models (1). It has also been recently confirmed to be an allosteric RIP1 kinase inhibitor, preotective in NMDa-mediated excitotoxicity and acute pathologies (2,3).
References 1. You Z., et al. (2008) J Cereb Blood Flow Metab. 28(9): 1564-1573.
2. Vandenabeele P., et al. (2010) Nat Rev Mol Cell Biol. 11:700-714.
3. Degterev A., et al. (2008) Nat Chem Biol. 4: 313-321.

Product Images

<p>Chemical structure of Necrostatin (SIH-213), a Inhibits necroptosis. CAS #: 4311-88-0. Molecular Formula: C13H13N3OS . Molecular Weight: 259.33 g/mol.</p>

Chemical structure of Necrostatin (SIH-213), a Inhibits necroptosis. CAS #: 4311-88-0. Molecular Formula: C13H13N3OS . Molecular Weight: 259.33 g/mol.

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