Discovery through Partnership | Excellence through Quality
| Product Name | R(-)-Gossypol |
| Description |
Bcl-2 inhibitor |
| Purity | >98% |
| CAS No. | 303-45-7 |
| Molecular Formula | C30H30O8 |
| Molecular Weight | 518.56 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inducer |
| Solubility | Soluble to 25 mM in ethanol and in DMSO. |
| Source | Synthetic |
| Appearance | Dark Yellow Solid |
| SMILES | CC1=CC2=C(C(=C(C(=C2C(C)C)O)O)C=O)C(=C1C3=C(C4=C(C=C3C)C(=C(C(=C4C=O)O)O)C(C)C)O)O |
| InChI | InChI=1S/C30H30O8/c1-11(2)19-15-7-13(5)21(27(35)23(15)17(9-31)25(33)29(19)37)22-14(6)8-16-20(12(3)4)30(38)26(34)18(10-32)24(16)28(2 |
| InChIKey | QBKSWRVVCFFDOT-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R62- Possible risk of impaired fertility R68- Possible risk of irreversible effects Hazard Phrases: H351 Precautionary Phrases: P281 |
| Cite This Product | R(-)-Gossypol (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-223) |
Biological Description
| Alternative Names | 1,1',6,6',7,7'-Hexahydroxy-5,5'-diisopropyl-3,3'-dimethyl-2,2'-binaphthalene-8,8'-dicarbaldehyde, Gossypol |
| Research Areas | Apoptosis, Cancer |
| PubChem ID | 3503 |
| Scientific Background | Gossypol is a natural phenol derived from the cotton plant, and is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. It has proapoptotic properties, due to the regulation of the Bax and Bcl2. It also reversibly inhibits calcineurin and binds to calmodulin (1, 2). |
| References |
1. www.bioscreening.net “Gossypol” 2. Carruthers N.J., Dowd M.K., and Stemmer P.M. (2007) Eur J Pharmacol. 555(2-3): 106-114. |
Product Images
Chemical structure of R(-)-Gossypol (SIH-223), a Bcl-2 inhibitor. CAS #: 303-45-7. Molecular Formula: C30H30O8. Molecular Weight: 518.56 g/mol.
Powered by Bioz
Reviews
There are no reviews yet.