Small Molecules - Apoptosis, Cellular Oxidative Stress,

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Product Name: Epothilone B
Catalog #: SIH-238-5MG
Alternative Names: Patupilone
Size: 5mg
Type: Inducer
Description: Microtubule stabilizing agent
Research Area: Apoptosis
CAS Number: 152044-54-7
Formula: C27H41NO6S
Molecular weight: 507.68
Source/Host: Synthetic
Purity: >99%
Solubility: Soluble to 10mM in DMSO.
Appearance: White Solid
Storage Temp: -20°C
Shipping Temp: Blue Ice or 4°C
Safety Phrases: Classification: Caution: Substance not yet fully tested.

Safety Phrases: S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Datasheet: SIH 238 Epothilone B Apoptosis Inducer
Price: $699.00 USD Add to Cart Bulk Quote

Structure of Epothilone B

Research Background: Epothilone are a new class of cancer drugs. They prevent cancer cells from dividing by interfering with tubulin (1). Epithilone B possess the same biological effects as paclitaxel in both invitro and cultured cells, because they share the same binding site (2). Epothilone has also been shown to induce tubulin polymerization into microtubules without the presence of GTP. And it also causes cell cycle arrest at the G2-M transition phase, leading to eventual cell apoptosis (3).
References: 1. Rosenberg S., Devita V.T., Hellman S. (2005) Cancer: Principles & Practice of Oncology: Lippincott Williams and Wilkins.
2. Julien B., Shah S. (2002) Antimicrob Agents Chemother. 46(9): 2772.
3. Balog D.M., et al. (1996) Angew Chem. 108: 2976.

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