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| Product Name | Taxol |
| Description |
Microtubule stabilizer |
| Purity | >98% (TLC); NMR (Conforms) |
| CAS No. | 33069-62-4 |
| Molecular Formula | C47H51NO14 |
| Molecular Weight | 853.9 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inducer |
| Solubility | Soluble in DMSO, ethanol or acetonitrile |
| Source | Synthetic |
| Appearance | White solid |
| SMILES | CC1=C2[C@@]([C@]([C@H]([C@@H]3[C@]4([C@H](OC4)C[C@@H]([C@]3(C(=O)[C@@H]2OC(=O)C)C)O)OC(=O)C)OC(=O)C5=CC=CC=C5)(C[C@@H]1OC(=O)[C@H](O)[C@@H](NC(=O)C6=CC=CC=C6)C7=CC=CC=C7)O)(C)C |
| InChI | InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20- |
| InChIKey | RCINICONZNJXQF-MZXODVADSA-N |
| Safety Phrases |
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R62- Possible risk of impaired fertility R68- Possible risk of irreversible effects Hazard Phrases: H318-H361f-H341-H332-H312-H302-H335-H315-H334-H317 Precautionary Phrases: P280-P305+P351+P338-P260-P261-P342+P311 |
| Cite This Product | Taxol (StressMarq Biosciences, Canada, Cat # SIH-239) |
Biological Description
| Alternative Names | (2α,5β,7β,10β,13α)-4,10-Diacetoxy-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1,7-dihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate, Paclitaxel |
| Research Areas | Apoptosis, Cancer |
| PubChem ID | 36314 |
| Scientific Background | Paclitaxel is a mitotic inhibitor that promotes and stabilizes tubulin polymerization, causing cell cycle arrest (1). Induces autocatalytic activation of caspase-10 in CCRF-HSB-2 cells, triggering apoptosis (2). |
| References |
1. Wani M., Taylor H., Wall M., Coggon P., and McPhail A. (1971) J Am Chem Soc. 93(9): 2325-2327. 2. Park S.J., et al. (2004) J Biol Chem. 279(49): 51057-51067. |
Product Images
Chemical structure of Taxol (SIH-239), a Microtubule stabilizing agent. CAS #: 33069-62-6. Molecular Formula: C47H51NO14. Molecular Weight: 853.9 g/mol.
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Based on validation through cited publications.