Small Molecules - Apoptosis, Cellular Oxidative Stress,

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Product Name: Irinotecan HCl
Catalog #: SIH-243-250MG
Alternative Names: CPT11, Camptothecin 11
Size: 250mg
Type: Inducer
Description: Topoisomerase I inhibitor
Research Area: Apoptosis
CAS Number: 100286-90-6
Formula: C33H38N4O6*HCl
Molecular weight: 623.14
Source/Host: Synthetic
Purity: >99%
Solubility: Soluble to 50mg/mL in DMSO.
Appearance: Yellow solid
Storage Temp: -20°C
Shipping Temp: Blue Ice or 4°C
Safety Phrases: Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.

Safety Phrases: S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible)

Risk Phrases: R20/21/22 - Harmful by inhilation, in contact with skin and if swallowed
R62 - Possible risk of impaired fertility
R68 - Possible risk of irreversible effects

Hazard Phrases: H302
Datasheet: SIH 243 Irinotecan HCl Apoptosis Inducer
Price: $359.00 USD Add to Cart Bulk Quote

Structure of Irinotecan HCl

Research Background: Irinotecan is a topoisomerase 1 inhibitor, which prevents DNA from unwinding. Chemically it is a semisynthetic analogue of the natural alkaloid camptothecin. It is activated by hydrolysis to SN-38 which is then inactivated by glucuronidation by UGT1A1. This inactivation eventually leads to inhibition of both DNA replication and transcription (1, 2).
References: 1. Innocentri F., et al. (2004) J Clin. Oncol. 22(8): 1382-1388.
2. O’Dwyer P.J., and Catalano R.B. (2006) J Clin Oncol. 24(28): 4534-4538.

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