Deguelin

Name: Deguelin
SKU: SIH-251
Availability: InStock

Akt inhibitor

Catalog No. SIH-251

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CAS No.	522-17-8
Molecular Formula	C23H22O6

SKU: SIH-251 Categories: Inducer, Small Molecules

Product Name	Deguelin
Description	Akt inhibitor
Purity	>98%
CAS No.	522-17-8
Molecular Formula	C₂₃H₂₂O₆
Molecular Weight	394.42
Field of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inducer
Solubility	Soluble to 50 mM in ethanol and to 100 mM in DMSO
Source	Synthetic
Appearance	Cream Solid
SMILES	CC1(C=CC2=C(O1)C=CC3=C2O[C@@H]4COC5=CC(=C(C=C5[C@@H]4C3=O)OC)OC)C
InChI	InChI=1S/C23H22O6/c1-23(2)8-7-12-15(29-23)6-5-13-21(24)20-14-9-17(25-3)18(26-4)10-16(14)27-11-19(20)28-22(12)13/h5-10,19-20H
InChIKey	ORDAZKGHSNRHTD-UXHICEINSA-N
Safety Phrases	Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Cite This Product	Deguelin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-251)

Alternative Names	(7aS,13aS)-9,10-Dimethoxy-3,3-dimethyl-13,13a-dihydro-3H-chromeno[3,4-b]pyrano[2,3-h]chromen-7(7aH)-one
Research Areas	Apoptosis, Cancer
PubChem ID	107935
Scientific Background	Deguelin is a rotenoid, and a naturally occurring insecticide. Deguelin displays anti-cancer activity by inhibiting the growth of pre-cancerous and cancerous cells (1). High doses may have negative effects on the heart, lungs and nerves however. Deguelin has also been shown to have a correlation with Parkinson’s disease in rats (2).
References	1. Lee H.Y. (2004) Biochem Pharmacol. 68(6): 1119-1124. 2. Caboni P., et al. (2004) Chem Res. Toxicol. 17(11): 1540-1548.

Chemical structure of Deguelin (SIH-251), a Akt inhibitor. CAS #: 522-17-8. Molecular Formula: C23H22O6. Molecular Weight: 394.42 g/mol.

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