Phenylbutyrate Na

HDAC inhibitor

Catalog No. SIH-255

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CAS No. 1716-12-7
Molecular Formula C10H11NaO2
SKU: SIH-255 Categories: ,

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SIH-255_Phenylbutyrate_Na_Chemical_Structure.png
Product Name Phenylbutyrate Na
Description

HDAC inhibitor

Purity >98%
CAS No. 1716-12-7
Molecular Formula C10H11NaO2
Molecular Weight 186.18
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inducer
Solubility Soluble to 1100 mM in water and 100 mM in DMSO
Source Synthetic
Appearance White solid
SMILES C1=CC=C(C=C1)CCCC(=O)[O-].[Na+]
InChI InChI=1S/C10H12O2.Na/c11-10(12)8-4-7-9-5-2-1-3-6-9;/h1-3,5-6H,4,7-8H2,(H,11,12);/q;+1/p-1
InChIKey VPZRWNZGLKXFOE-UHFFFAOYSA-M
Safety Phrases Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Cite This Product Phenylbutyrate Na (StressMarq Biosciences, Canada, Cat # SIH-255)

Biological Description

Alternative Names Sodium 4-phenylbutanoate, 4-PB
Research Areas Apoptosis, Cancer, Cancer Growth Inhibitors, HDAC Inhibitors
PubChem ID 5258
Scientific Background Sodium phenylbutyrate is metabolized in the human body by beta-oxidation to phenylacetate, which is then conjugated with glutamine to phenylacetylglutamine, which is eliminated with urine (1). It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of fetal hemoglobin through transcriptional activation of gamma-globin gene (2).
References 1. Batashaw M.L., MacArthur R.B., and Tuchman M. (2001) J Pediatr. 138: S46-54.
2. Melichar B., et al. (1998) Clin Cancer Res. 4:3069-3076.

Product Images

<p>Chemical structure of Phenylbutyrate Na (SIH-255), a Histone deacetylase inhibitor. CAS #: 1716-12-7. Molecular Formula: C10H11NaO2. Molecular Weight: 186.18 g/mol.</p>

Chemical structure of Phenylbutyrate Na (SIH-255), a Histone deacetylase inhibitor. CAS #: 1716-12-7. Molecular Formula: C10H11NaO2. Molecular Weight: 186.18 g/mol.

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