Small Molecules - Apoptosis, Cellular Oxidative Stress,

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Product Name: Phenylbutyrate Na
Catalog #: SIH-255-500MG
Alternative Names: 4-PB, Sodium Phenylbutyrate
Size: 500mg
Type: Inducer
Description: Histone deacetylase inhibitor
Research Area: Apoptosis
CAS Number: 1716-12-7
Formula: C10H11NaO2
Molecular weight: 186.18
Source/Host: Synthetic
Purity: >99%
Solubility: Soluble to 1100mM in water and 100mM in DMSO
Appearance: White solid
Storage Temp: -20°C
Shipping Temp: Blue Ice or 4°C
Safety Phrases: Classification: Caution: Substance not yet fully tested.

Safety Phrases: S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Datasheet: SIH 255 Sodium Phenylbutyrate Apoptosis Inducer
Price: $54.00 USD Add to Cart Bulk Quote

Structure of Sodium Phenylbutyrate

Research Background: Sodium phenylbutyrate is metabolized in the human body by beta-oxidation to phenylacetate, which is then conjugated with glutamine to phenylacetylglutamine, which is eliminated with urine (1). It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of fetal hemoglobin through transcriptional activation of gamma-globin gene (2).
References: 1. Batashaw M.L., MacArthur R.B., and Tuchman M. (2001) J Pediatr. 138: S46-54.
2. Melichar B., et al. (1998) Clin Cancer Res. 4:3069-3076.

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