Small Molecules - Apoptosis, Cellular Oxidative Stress,

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Product Name: Sulindac Sulfone
Catalog #: SIH-262-50MG
Size: 50mg
Type: Inducer
Description: Modulates beta-catenin-mediated effects
Research Area: Apoptosis
CAS Number: 59864-04-9
Formula: C20H17FO4S
Molecular weight: 372.41
Source/Host: Synthetic
Purity: >99%
Solubility: Soluble to 25mM in DMSO, 3mM in ethanol.
Appearance: Yellow solid
Storage Temp: -20°C
Shipping Temp: Blue Ice or 4°C
Safety Phrases: Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.

Safety Phrases: S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Datasheet: SIH 262 Sulindac Sulfone Apoptosis Inducer
Price: $319.00 USD Add to Cart Bulk Quote

Structure of Sulindac Sulfone

Research Background: Sulindac is a nonsteroidal anti-inflammatory drug that is known to prevent recurrence and reduce colorectal polyps. It is a prodrug that is metabolized to a sulfide and sulfone derivative in vivo. The mechanism of action of both is the selective induction of apoptosis. The anti-inflammatory properties of sulindac are mediated by COX inhibition (1, 2).
References: 1. Frahm S., et al. (2004) Cancer Cell Int. 4:4.
2. Piazza G.A., et al. (1997) Cancer Res. 57(12): 2452-2459.

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