Mitomycin C

DNA synthesis inhibitor

Catalog No. SIH-246

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CAS No. 50-07-7
Molecular Forumla C15H18N4O5

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Overview

Product Name Mitomycin C
Description

DNA synthesis inhibitor

Purity >98%
CAS No. 50-07-7
Molecular Formula C15H18N4O5
Molecular Weight 334.33

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble to 100 mM in DMSO, 5 mM water, and to 5 mM Ethanol
Source Synthetic
Appearance Dark Purple Crystalline Solid
SMILES CC1=C(C(=O)C2=C(C1=O)N3C[[email protected]]4[C@@H]([C@@]3([C@@H]2COC(=O)N)OC)N4)N
InChI InChI=1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H
InChIKey NWIBSHFKIJFRCO-WUDYKRTCSA-N
Safety Phrases Classification: Very toxic. May be fatal if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible)
Risk Phrases:
R26/27/28 - Very Toxic by inhalation, in contact with skin and if swallowed
R46 - May cause heritable genetic damage
R61 - May cause harm to the unborn child
R62 - Possible risk of impaired fertility
Hazard Phrases:
H302-H351
Precautionary Phrases:
P281
Cite This Product Mitomycin C (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-246)

Biological Description

Alternative Names [(1aS,8S,8aR,8bS)-6-Amino-8a-methoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazireno[2',3':3,4]pyrrolo[1,2-a]indol-8-yl]methyl carbamate, Ametycine
Research Areas Cancer, Apoptosis
PubChem ID 5746
Scientific Background The mitomycins are a family of aziridine containing natural products. Mitomycin C is a chemotherapeutic agent because of its mechanism of potent DNA crosslinker, reductive activation followed by two N-alklyations. Both alkylations are sequence specific for a guanine nucleoside in the sequence 5’-CpG-3’ (1).
References 1. Tomasz M. (1995). Chem and Biol. 2(9): 575-579.

Product Images

Chemical structure of Mitomycin C (SIH-246), a DNA crosslinking and damaging agent. CAS #: 50-07-7. Molecular Formula: C15H18N4O5. Molecular Weight: 334.33 g/mol.

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