StressMarq Biosciences is a leading provider of high-quality fibrillar, oligomeric, and monomeric protein preparations—including alpha synuclein, tau, amyloid beta, TDP-43, SOD1, TTR and more—designed to support cutting-edge neurodegenerative disease research. With a focus on pathology-inducing protein aggregates, our products support the development of robust disease models and accelerate drug discovery for conditions such as Alzheimer’s, Parkinson’s, and ALS. StressMarq is committed to scientific excellence— empowering researchers worldwide with tools that accelerate discovery and translational research.

Beta Synuclein Pre-formed Fibrils (PFFs) & Monomers

Beta synuclein is a presynaptic protein closely related to alpha synuclein, sharing structural similarities but exhibiting distinct functional and pathological properties. Unlike alpha synuclein, beta synuclein does not aggregate under physiological conditions and is believed to help maintain vesicular membrane curvature. Wild-type beta synuclein has been shown to inhibit alpha synuclein aggregation, while mutant forms such as V70M and P123H have been linked to Dementia with Lewy Bodies (DLB).

StressMarq Biosciences offers a range of beta synuclein protein constructs, including pre-formed fibrils (PFFs) and monomers, designed for use in neurodegenerative disease research. Human beta synuclein PFFs do not induce endogenous alpha synuclein aggregation in primary rat hippocampal neurons, making them ideal as experimental controls in synucleinopathy studies. These reagents support investigations into protein interactions, aggregation dynamics, and disease-modifying mechanisms.

StressMarq manufactures wild-type beta synuclein fibrils and monomers for use in neurodegenerative disease research.

• Human Recombinant Beta Synuclein Pre-formed Fibrils (PFFs) | Catalog# SPR-457
• Human Recombinant Beta Synuclein Monomers | Catalog# SPR-405

TEM of Human Recombinant Beta Synuclein Pre-formed Fibrils (catalog# SPR-457)

Primary rat hippocampal neurons treated with human beta synuclein pre-formed fibrils (SPR-457) do not show Lewy body inclusion formation. Fibrils were sonicated 1 hour and added at 1 ug/mL concentration. A) Hoechst. B) pSer129. C) Merge.

1. Westphal, C.H., Chandra, S.S. (2013). J Biol Chem. 288(3):1829-40.
2. Yamin, F. et al. (2005) Biochemistry. 44, 9096-9107.
3. Hashimoto, M. et al. (2001) Neuron. 32,213-223.
4. Ohtake, H. et al. (2004). Neurology. 63(5):805-11.

Product Citations

StressMarq’s proteins for neurodegenerative disease research have been cited in many peer-reviewed scientific journals. 

• Astrocytic RNA editing regulates the host immune response to alpha-synuclein. D’Sa, K. et al. Sci Adv. Apr 2025.
  • Catalog# SPR-405: Human Recombinant Beta Synuclein Monomers

• Ultrasensitive detection of aggregated α-synuclein using quiescent seed amplification assay for the diagnosis of Parkinson’s disease. Mao, H. et al. Transl Neurodegener. Jul 2024.
  • Catalog# SPR-457: Human Recombinant Beta Synuclein Pre-formed Fibrils (Type 1)

Supplemental Learning Materials

Technical Support Resources

• Handling Instructions | Synucleins
• Protocols | Neuro Proteins
• Sonication Protocol | PFFs
• Frequently Asked Questions | Neuro Proteins

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