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| Product Name | Carnosic acid |
| Description |
PPARγ activator |
| Purity | >95% (HPLC); NMR(Conforms) |
| CAS No. | 07-09-50 |
| Molecular Formula | C20H28O4 |
| Molecular Weight | 332.43 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Activator |
| Solubility | Soluble in DMSO (50 mg/ml) |
| Source | Synthetic |
| Appearance | Off white to yellow solid |
| SMILES | CC(C)C1=C(C(=C2C(=C1)CC[C@@H]3[C@@]2(CCCC3(C)C)C(=O)O)O)O |
| InChI | InChI=1S/C20H28O4/c1-11(2)13-10-12-6-7-14-19(3,4)8-5-9-20(14,18(23)24)15(12)17(22)16(13)21/h10-11,14,21-22H,5-9H2,1-4H3,(H,23,24)/t14-,20+/m0/s1 |
| InChIKey | QRYRORQUOLYVBU-VBKZILBWSA-N |
| Safety Phrases |
Classification: Caution- Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes |
| Cite This Product | Carnosic acid (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-362) |
Biological Description
| Alternative Names | (4aR,10aS)-5,6-Dihydroxy-7-isopropyl-1,1-dimethyl-1,3,4,9,10,10a-hexahydro-2H-phenanthrene-4a-carboxylic acid |
| Research Areas | Apoptosis, Cancer |
| PubChem ID | 65126 |
| Scientific Background | Carnosic acid is a phenolic diterpene found in rosemary and sage, known for its potent antioxidant and neuroprotective properties. In neuroscience, carnosic acid has gained attention for its ability to activate the Nrf2-ARE pathway, a critical regulator of cellular defense against oxidative stress. This activation leads to the upregulation of detoxifying and antioxidant enzymes, offering protection against neuronal damage in models of Alzheimer’s, Parkinson’s, and ischemic stroke. Carnosic acid also exhibits anti-inflammatory effects by modulating microglial activation and cytokine production. Its dual action on oxidative stress and inflammation makes it a promising candidate for therapeutic development in neurodegenerative disease research. |
| References |
1. Schwarz K., Ternes W. (1992) Zeitschrift für Lebensmittel-Untersuchung und –Forschung. 195 (2): 99-103. 2. Chen J.H., et al. Chem. (2012) Res. Toxicol 25:1893. 3. Takahashi T., et al. (2009) Biochem. Biophys. Res. Commun. 382:549. 4. Kar S., et al. (2012) Apoptosis. 17:1735. 5. Barni M.V., et al. (2012) Oncol. Rep. 27:1041. |
Product Images
Chemical structure of Carnosic acid (SIH-362), a REDOX& GSH induction. CAS #: 3650-09-7. Molecular Formula: C20H28O4. Molecular Weight: 332.43 g/mol.
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