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| Product Name | PAC-1 |
| Description |
Procaspase-3 activator |
| Purity | >98% (HPLC); NMR (conforms) |
| CAS No. | 315183-21-2 |
| Molecular Formula | C23H28N4O2 |
| Molecular Weight | 392.5 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Activator |
| Solubility | May be dissolved in DMSO (35 mg/ml); or ethanol (15 mg/ml) |
| Source | Synthetic |
| Appearance | Off-White powder |
| SMILES | O=C(N/N=C/C3=CC=CC(CC=C)=C3O)CN(CC2)CCN2CC1=CC=CC=C1 |
| InChI | InChI=1S/C23H28N4O2/c1-2-7-20-10-6-11-21(23(20)29)16-24-25-22(28)18-27-14-12-26(13-15-27)17-19-8-4-3-5-9-19/h2-6,8-11,16,29H,1,7,12-15,17-18H2,(H,25,28)/b24-16+ |
| InChIKey | YQNRVGJCPCNMKT-LFVJCYFKSA-N |
| Safety Phrases | GHS Classifcation: GHSO9 Hazardous to the aquatic environment, Acute hazard, category1, Chronic hazard, categories 1,2 Hazard statement(s): H400 |
| Cite This Product | PAC-1 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-569) |
Biological Description
| Alternative Names | 4-(Phenylmethyl)-1-piperazineacetic acid [[2-hydroxy-3-(2-propenyl)phenyl]-methylene]hydrazide |
| Research Areas | Apoptosis, Cancer, Caspases, Cell Cycle, Cell Signaling, Neuroscience |
| PubChem ID | 9675990 |
| Scientific Background | PAC-1 is a small molecule that directly activates procaspase-3 by chelating inhibitory zinc ions, facilitating its autoactivation into caspase-3. While primarily studied in oncology for its pro-apoptotic effects, PAC-1 is also used in neuroscience to investigate caspase-mediated neuronal apoptosis. It serves as a tool for exploring programmed cell death pathways in neurodegenerative diseases and for evaluating neuroprotective interventions that target apoptotic signaling. |
| References |
1. Putt K.S., et al., (2006) Nat. Chem. Biol. 2:543. 2. Peterson Q.P., et al., (2009) J. Mol. Biol. 388:144. |
Product Images
Chemical structure of PAC-1 (SIH-569), a Procaspase-3 activator . CAS #: 315183-21-2. Molecular Formula: C23H28N4O2. Molecular Weight: 392.5 g/mol.
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