PAC-1

Name: PAC-1
SKU: SIH-569
Availability: InStock

Procaspase-3 activator

Catalog No. SIH-569

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CAS No.	315183-21-2
Molecular Formula	C23H28N4O2

SKU: SIH-569 Categories: Activator, Small Molecules

Product Name	PAC-1
Description	Procaspase-3 activator
Purity	>98% (HPLC); NMR (conforms)
CAS No.	315183-21-2
Molecular Formula	C₂₃H₂₈N₄O₂
Molecular Weight	392.5
Field of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Activator
Solubility	May be dissolved in DMSO (35 mg/ml); or ethanol (15 mg/ml)
Source	Synthetic
Appearance	Off-White powder
SMILES	O=C(N/N=C/C3=CC=CC(CC=C)=C3O)CN(CC2)CCN2CC1=CC=CC=C1
InChI	InChI=1S/C23H28N4O2/c1-2-7-20-10-6-11-21(23(20)29)16-24-25-22(28)18-27-14-12-26(13-15-27)17-19-8-4-3-5-9-19/h2-6,8-11,16,29H,1,7,12-15,17-18H2,(H,25,28)/b24-16+
InChIKey	YQNRVGJCPCNMKT-LFVJCYFKSA-N
Safety Phrases	GHS Classifcation: GHSO9 Hazardous to the aquatic environment, Acute hazard, category1, Chronic hazard, categories 1,2 Hazard statement(s): H400
Cite This Product	PAC-1 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-569)

Alternative Names	4-(Phenylmethyl)-1-piperazineacetic acid [[2-hydroxy-3-(2-propenyl)phenyl]-methylene]hydrazide
Research Areas	Apoptosis, Cancer, Caspases, Cell Cycle, Cell Signaling, Neuroscience
PubChem ID	9675990
Scientific Background	PAC-1 is a procaspase-activating compound, directly activating procaspase-3, producing caspase-3 (1); it is less potent at activating procaspase-7. It induces apoptosis in a variety of cancer cell lines by activation involving sequestering inhibitory zinc ions thus allowing procaspase-3 to autoactivate (2).
References	1. Putt K.S., et al., (2006) Nat. Chem. Biol. 2:543. 2. Peterson Q.P., et al., (2009) J. Mol. Biol. 388:144.

Chemical structure of PAC-1 (SIH-569), a Procaspase-3 activator . CAS #: 315183-21-2. Molecular Formula: C23H28N4O2. Molecular Weight: 392.5 g/mol.

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