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| Product Name | SKA-31 |
| Description |
KCa3.1 and KCa2 channel activator |
| Purity | >98% (TLC); NMR (Conforms) |
| CAS No. | 40172-65-4 |
| Molecular Formula | C11H8N2S |
| Molecular Weight | 200.1 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Activator |
| Solubility | May be dissolved in DMSO (40mg/ml) |
| Source | Synthetic |
| Appearance | Off-white powder |
| SMILES | C1=CC=C2C(=C1)C=CC3=C2N=C(S3)N |
| InChI | InChI=1S/C11H8N2S/c12-11-13-10-8-4-2-1-3-7(8)5-6-9(10)14-11/h1-6H,(H2,12,13) |
| InChIKey | FECQXVPRUCCUIL-UHFFFAOYSA-N |
| Safety Phrases |
Signal word: Warning Hazard statement(s): H302 Harmful if swallowed. H319 Causes serious eye irritation. Precautionary statement(s): P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear eye protection/ face protection. P301 + P312 + P330 IF SWALLOWED: Call a POISON CENTER/ doctor if you feel unwell. Rinse mouth. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337 + P313 If eye irritation persists: Get medical advice/ attention. P501 Dispose of contents/ container to an approved waste disposal plant. |
| Cite This Product | SKA-31 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-595) |
Biological Description
| Alternative Names | Naphtho[1,2-d]thiazol-2-ylamine |
| Research Areas | Neuroscience, Neurotransmission, Neurotransmitter Receptors |
| PubChem ID | 94880 |
| Scientific Background | SKA 31 is an activator of KCa3.1 and KCa2 channels. It has significant blood-pressure reducing activity in experimentally hypertensive mice, suggesting potassium channel activation as a therapeutic target for hypertension. |
| References | 1. Sankaranarayanan A., et al. (2009) Mol Pharmacol. 75 (2): 281-295. |
Product Images
Chemical structure of SKA-31 (SIH-595), a KCa3.1 and KCa2 channel activator. CAS #: . Molecular Formula: C11H8N2S. Molecular Weight: 200.1 g/mol.
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