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| Product Name | Adiporon |
| Description |
Adiponectin receptor agonist |
| Purity | >98% (TLC); NMR (Conforms) |
| CAS No. | 924416-43-3 |
| Molecular Formula | C27H28N2O3 |
| Molecular Weight | 428.5 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Agonist |
| Solubility | May be dissolved in DMSO (40 mg/ml); or ethanol (20 mg/ml) |
| Source | Synthetic |
| Appearance | White crystalline powder |
| SMILES | N2(CCC(CC2)NC(=O)COc3ccc(cc3)C(=O)c4ccccc4)Cc1ccccc1 |
| InChI | InChI=1S/C27H28N2O3/c30-26(28-24-15-17-29(18-16-24)19-21-7-3-1-4-8-21)20-32-25-13-11-23(12-14-25)27(31)22-9-5-2-6-10-22/h1-14,24H,15-20H2,(H,28,30) |
| InChIKey | SHHUPGSHGSNPDB-UHFFFAOYSA-N |
| Safety Phrases | Not a hazardous substance or mixture. |
| Cite This Product | Adiporon (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-635) |
Biological Description
| Alternative Names | 2-(4-Benzoylphenoxy)-N-(1-benzylpiperidin-4-yl)acetamide |
| Research Areas | Alzheimer's Disease, Atherosclerosis, Cardiovascular System, Diabetes Associated, Neurodegeneration, Neuroscience, Oxidative Stress, Tangles & Tau |
| PubChem ID | 16307093 |
| Scientific Background | Adiporon is a potent and selective agonist of adiponectin receptors AdipoR1 and AdipoR2, mimicking adiponectin's metabolic effects. It activates AMPK and PPARα signaling pathways, improving insulin sensitivity and reducing oxidative stress. In neurodegenerative disease models, Adiporon has been shown to clear neurofibrillary tangles and rescue tauopathy-associated neuronal defects. Its systemic metabolic benefits, combined with neuroprotective properties, position it as a promising candidate for therapeutic development in Alzheimer's disease and other tauopathies. |
| References |
1. M Okada-Iwabu et al. (2013) Nature. 503:493 2. S Lee and HB Kwak (2014)J. Exerc. Rehabil. 10:54 3. Y Zhang et al. (2015) Am. J. Physiol. Endocrinol. Metab. 309:E275. 4. E.R. McGregor et al. (2025) Comm Biol. 8 : https://www.nature.com/articles/s42003-024-07391-z |
Product Images
Chemical structure of Adiporon (SIH-635), a Adiponectin Receptor Agonist. CAS #: 924416-43-3. Molecular Formula: C27H28N2O3. Molecular Weight: 428.5 g/mol.
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