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| Product Name | Kainic acid |
| Description |
Kainate agonist |
| Purity | >99% (HPLC) |
| CAS No. | 58002-62-3 |
| Molecular Formula | C10H15NO4•H2O |
| Molecular Weight | 213.2 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Agonist |
| Solubility | May be dissolved in water (10 mg/ml) |
| Source | Synthetic |
| Appearance | White powder |
| SMILES | CC(=C)[C@H]1CN[C@@H]([C@H]1CC(=O)O)C(=O)O |
| InChI | InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1 |
| InChIKey | VLSMHEGGTFMBBZ-OOZYFLPDSA-N |
| Safety Phrases |
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection |
| Cite This Product | Kainic acid (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-364) |
Biological Description
| Alternative Names | (2S,3S,4S)-3-(carboxymethyl)-4-(prop-1-en-2-yl)-pyrrolidine-2-carboxylic acid, Monohydrate |
| Research Areas | Glutamate Receptors, Ion Channels, Kainate Receptors, Neuroscience, Neurotransmitter Receptors |
| PubChem ID | 10255 |
| Scientific Background | Kainic acid is a potent agonist of kainate receptors, a subtype of ionotropic glutamate receptors. It is commonly used to induce excitotoxicity and seizure-like activity in animal models, mimicking aspects of neurodegenerative diseases and epilepsy. In neuroscience, kainic acid is employed to study neuronal death, synaptic remodeling, and neuroinflammation. Its ability to trigger excitotoxic damage provides insights into glutamate-mediated neurodegeneration and the role of excitatory neurotransmission in brain pathology. Kainic acid models are instrumental in evaluating neuroprotective strategies and understanding the mechanisms of neuronal injury. |
| References | 1. Watkins J.C., et al. (1981) Ann. Rev. Pharmacol. Toxicol. 21: 165. |
Product Images
Chemical structure of Kainic acid (SIH-364), a Neuro-excitant/ Kainate agonist. CAS #: 58002-62-3. Molecular Formula: C10H15NO4 (*H2O). Molecular Weight: 213.2 g/mol.
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