Discovery through Partnership | Excellence through Quality
| Product Name | Troglitazone |
| Description |
PPARgamma agonist |
| Purity | >98% |
| CAS No. | 97322-87-7 |
| Molecular Formula | C24H27NO5S |
| Molecular Weight | 441.54 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Agonist |
| Solubility | Soluble to 100 mM in DMSO and to 10 mM in ethanol |
| Source | Synthetic |
| Appearance | White solid |
| SMILES | CC1=C(C2=C(CCC(O2)(C)COC3=CC=C(C=C3)CC4C(=O)NC(=O)S4)C(=C1O)C)C |
| InChI | InChI=1S/C24H27NO5S/c1-13-14(2)21-18(15(3)20(13)26)9-10-24(4,30-21)12-29-17-7-5-16(6-8-17)11-19-22(27)25-23(28)31-19/h5-8,19,26H,9-12H2,1-4H3,(H, |
| InChIKey | GXPHKUHSUJUWKP-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed R40 - Limited evidence of a carcinogenic effect |
| Cite This Product | Troglitazone (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-260) |
Biological Description
| Alternative Names | 5-{4-[(6-Hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromen-2-yl)methoxy]benzyl}-1,3-thiazolidine-2,4-dione, Rezulin |
| Research Areas | Apoptosis, Cancer |
| PubChem ID | 5591 |
| Scientific Background | Troglitazone is a thiazolidinedione class drug that acts as a dual agonist of peroxisome proliferator-activated receptors (PPARα and PPARγ). While primarily developed for diabetes, troglitazone has shown potential in neurodegenerative disease research due to its anti-inflammatory and antioxidant properties. It modulates gene expression involved in lipid metabolism, glucose homeostasis, and mitochondrial function. These effects may help protect neurons from oxidative stress and inflammation, key contributors to neurodegeneration. |
| References |
1. Lambe K.G. and Tugwood J.D. (1996) Eur J Biochem. 239(1): 1-7. 2. Aljada A., et al. (2001) J Clin Endocrinol Metab. 86(7): 3250-3256. |
Product Images
Chemical structure of Troglitazone (SIH-260), a PPARgamma agonist. CAS #: 97322-87-7. Molecular Formula: C24H27NO5S. Molecular Weight: 441.54 g/mol.
Powered by Bioz
Reviews
There are no reviews yet.