TTNPB

Name: TTNPB
SKU: SIH-608
Availability: InStock

Retinoic acid receptor agonist

Catalog No. SIH-608

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CAS No.	71441-28-6
Molecular Formula	C24H28O2

SKU: SIH-608 Categories: Agonist, Small Molecules

Product Name	TTNPB
Description	Retinoic acid receptor agonist
Purity	>98% (HPLC); NMR (conforms)
CAS No.	71441-28-6
Molecular Formula	C₂₄H₂₈O₂
Molecular Weight	348.5
Field of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Agonist
Solubility	May be dissolved in DMSO (4 mg/ml)
Source	Synthetic
Appearance	Off-white powder
SMILES	CC(=CC1=CC=C(C=C1)C(=O)O)C2=CC3=C(C=C2)C(CCC3(C)C)(C)C
InChI	InChI=1S/C24H28O2/c1-16(14-17-6-8-18(9-7-17)22(25)26)19-10-11-20-21(15-19)24(4,5)13-12-23(20,2)3/h6-11,14-15H,12-13H2,1-5H3,(H,25,26)/b16-14+
InChIKey	FOIVPCKZDPCJJY-JQIJEIRASA-N
Safety Phrases	Classification: Danger. Hazard Statements H315 - H319 - H335 - H360 Precautionary Statements P202 - P261 - P264 - P302 + P352 - P305 + P351 + P338 - P308 + P313
Cite This Product	TTNPB (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-608)

Alternative Names	4-[(E)-2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl]benzoic acid; Ro 13-7410; AGN-191183
Research Areas	Apoptosis, Cancer, Stem Cells
PubChem ID	5289501
Scientific Background	TTNPB is an analog of retinoic acid that potently and selectively activates retinoic acid receptors (1). Enables chemical reprogramming (without genetic factors) of mouse embryonic fibroblasts to induced pluripotent stem (iPS) cells, in combination with CHIR99021, Tranylcypromine, Valproic Acid, 3-Deazaneplanocin A, and E-616452 (2). And it Induces the in vitro growth and differentiation to granulocytes of myeloid progenitors isolated from myelodysplastic syndrome (MDS) patients (3).
References	1. Beard R.L., et al. (1995) J Med Chem. 38 (15): 2820-2829. 2. Hou P. et al. (2013) Science. 341 (6146): 651-654. 3. Fabian I. (1987) Leukemia Research. 11 (7): 635-640.

Chemical structure of TTNPB (SIH-608), a Retinoid RAR agonist. CAS #: 71441-28-6. Molecular Formula: C24H28O2. Molecular Weight: 348.5 g/mol.

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