Advancing the Frontiers of Neurodegenerative Disease Research
| Product Name | XIB4035 |
| Description |
GDNF signaling enhancer |
| Purity | >98% (TLC); NMR (Conforms) |
| CAS No. | 10023-54-8 |
| Molecular Formula | C26H31Cl2N3 • 3H3PO4 |
| Molecular Weight | 750.4 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Agonist |
| Solubility | May be dissolved in DMSO (25 mg/ml, warm) |
| Source | Synthetic |
| Appearance | Light-brown powder |
| SMILES | CCN(CC)CCCC(C)NC1=C2C=CC(=CC2=NC(=C1)/C=C/C3=CC=CC=C3Cl)Cl |
| InChI | InChI=1S/C26H31Cl2N3/c1-4-31(5-2)16-8-9-19(3)29-26-18-22(14-12-20-10-6-7-11-24(20)28)30-25-17-21(27)13-15-23(25)26/h6-7,10-15,17-19H,4-5,8-9,16H2,1-3H3,(H,29,30)/b14-12+ |
| InChIKey | CMLVHSVFSYNMGM-WYMLVPIESA-N |
| Safety Phrases |
Classification: Danger Hazard statements : H301 Toxic if swallowed. H413 May cause long lasting harmful effects to aquatic life. Precautionary statements : P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P273 Avoid release to the environment. P301 + P310 + P330 IF SWALLOWED: Immediately call a POISON CENTER/ doctor. Rinse mouth. P405 Store locked up. P501 Dispose of contents/ container to an approved waste disposal plant. |
| Cite This Product | XIB4035 (StressMarq Biosciences | Victoria, BC CANADA | Catalog# SIH-646) |
Biological Description
| Alternative Names | (E)-N4-(7-chloro-2-(2-chlorostyryl)quinolin-4-yl)-N1,N1-diethylpentane-1,4-diamine, 3(H3PO4) |
| Research Areas | ALS Disease, Ion Channels, Neurodegeneration, Neuroscience, Neurotransmission, Parkinson's Disease |
| PubChem ID | 5708341 |
| Scientific Background | XIB4035 is a small-molecule GFRα1 agonist and GDNF pathway modulator with neuroprotective and neuroregenerative activity. It activates RET signaling and promotes neurite outgrowth, mimicking key effects of the neurotrophic factor GDNF. The GDNF–GFRα1–RET pathway is highly relevant to neurodegeneration research. In a Parkinson’s disease mouse model, RET was shown to be essential for the neuroprotective and neuroregenerative effects of GDNF, supporting the use of XIB4035 as a tool to study neuronal survival and repair mechanisms. |
| References |
1. Tokugawa et al. Neurochemical International (2003): XIB4035 activates GFRα1/RET signaling and promotes neurite outgrowth. 2. Drinkut et al. Cell Death & Disease (2016): RET is required for GDNF-mediated neuroprotection in Parkinson’s disease models. https://pmc.ncbi.nlm.nih.gov/articles/PMC5059866/ |
Product Images
Chemical structure of XIB4035 (SIH-646), a GDNF Signaling Enhancer. CAS #: 10023-54-8. Molecular Formula: C26H31Cl2N3 • 3H3PO4. Molecular Weight: 750.4 g/mol.
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