Amiodarone Hydrochloride

Autophagy inducer

Catalog No. SIH-393

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CAS No. 19774-82-4
Molecular Formula C25H29I2NO3•HCl
SKU: SIH-393 Categories: ,

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SIH-393_Amiodarone_Hydrochloride_Chemical_Structure.png
Product Name Amiodarone Hydrochloride
Description

Autophagy inducer

Purity >99%
CAS No. 19774-82-4
Molecular Formula C25H29I2NO3•HCl
Molecular Weight 681.77
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inducer
Solubility Soluble to 50 mM in DMSO
Source Synthetic
Appearance White solid
SMILES [H+].C1=CC=CC2=C1C(=C(O2)CCCC)C(=O)C3=CC(=C(OCCN(CC)CC)C(=C3)I)I.[Cl-]
InChI InChI=1S/C25H29I2NO3.ClH/c1-4-7-11-22-23(18-10-8-9-12-21(18)31-22)24(29)17-15-19(26)25(20(27)16-17)30-14-13-28(5-2)6-3;/h8-10,12,15-16H,4-7,11,13-14H2,1-3H3;1H
InChIKey ITPDYQOUSLNIHG-UHFFFAOYSA-N
Safety Phrases Classification: D1B- Toxic Material Causing Immediate and Serious, Toxic Effects, Toxic by inhalation.
Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H303- May be harmful if swallowed.
H312 + H332- Harmful in contact with skin or if inhaled
Precautionary statements:
P280- Wear protective gloves/ protective clothing.
Cite This Product Amiodarone Hydrochloride (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-393)

Biological Description

Alternative Names 2-Butyl-3-benzofuranyl-4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl ketone hydrochloride
Research Areas Autophagy, Cancer
PubChem ID 441325
Scientific Background Amiodarone is a non-selective ion channel blocker. It has been found, when used in Saccharomyces cerevisiae, to induce an influx of Ca2+ followed by mitochondrial fragmentation and subsequent cell death. Amiodarone has also been shown to induce autophagy by inhibiting mTORC1. Lastly, Amiodarone has broad-spectrum fungicidal activity.
References 1. Zhang Y., et al. (2007). J Biol Chem. 282(52): 37844-53.
2. Balgi A., et al. (2009). PLoS One. 4(9): e7124.

Product Images

<p>Chemical structure of Amiodarone Hydrochloride (SIH-393), a Autophagy inducer. CAS #: 19774-82-4. Molecular Formula: C25H29I2NO3.HCl. Molecular Weight: 681.77 g/mol.</p>

Chemical structure of Amiodarone Hydrochloride (SIH-393), a Autophagy inducer. CAS #: 19774-82-4. Molecular Formula: C25H29I2NO3.HCl. Molecular Weight: 681.77 g/mol.

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