Aripiprazole

Dopamine D2 receptor antagonist.

Catalog No. SIH-630

0 out of 5 based on 0 customer ratings
CAS No. 129722-12-9
Molecular Formula C23H27Cl2N3O2
SKU: SIH-630 Categories: ,

Clear
SIH-630-Aripiprazole-Chemical-Structure.png
Product Name Aripiprazole
Description

Dopamine D2 receptor antagonist.

Purity 98% (TLC); NMR (Conforms)
CAS No. 129722-12-9
Molecular Formula C23H27Cl2N3O2
Molecular Weight 448.4
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Antagonist
Solubility May be dissolved in DMSO (30 mg/ml); or ethanol (5 mg/ml, warm)
Source Synthetic
Appearance White powder
SMILES C1CC(=O)NC2=C1C=CC(=C2)OCCCCN3CCN(CC3)C4=C(C(=CC=C4)Cl)Cl
InChI InChI=1S/C23H27Cl2N3O2/c24-19-4-3-5-21(23(19)25)28-13-11-27(12-14-28)10-1-2-15-30-18-8-6-17-7-9-22(29)26-20(17)16-18/h3-6,8,16H,1-2,7,9-15H2,(H,26,29)
InChIKey CEUORZQYGODEFX-UHFFFAOYSA-N
Safety Phrases Classification: Danger
GHS Hazard Statements,
H301 (62.7%): Toxic if swallowed [Danger Acute toxicity, oral]
H302 (35.3%): Harmful if swallowed [Warning Acute toxicity, oral]
H361 (15.7%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]
H413 (13.7%): May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard]

Precautionary Statement Codes,: P203, P264, P270, P273, P280, P301+P316, P301+P317, P318, P321, P330, P405, and P501
Cite This Product Aripiprazole (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-630)

Biological Description

Alternative Names 7-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydro-2(1H)-quinolinone; OPC-14597
Research Areas Alzheimer's Disease, Neurodegeneration, Neuroscience
PubChem ID 60795
Scientific Background Aripiprazole is an atypical antipsychotic with a unique pharmacological profile, acting as a partial agonist at dopamine D2 receptors and serotonin 5-HT1A receptors, and as an antagonist at 5-HT2A receptors. It is clinically used to treat schizophrenia and bipolar disorder and has shown efficacy in managing psychosis in Alzheimer’s disease. Aripiprazole also modulates reward pathways and has been shown to reduce drug-seeking behavior in animal models. Its dopaminergic and serotonergic modulation makes it relevant in neuropsychiatric and neurodegenerative research.
References 1.,B Green Curr. Med. Res. Opin. 2004 20:207
2.,T Kikuchi et al. J. Pharmacol. Exp. Ther. 1995 274:329
3.,S Madhusoodanan et al. Clin. Interv. Aging. 2008 3:491
4.,MW Feltenstein et al. Biol. Psychiatry 2007 61:582

Product Images

<p>Chemical structure of Aripiprazole (SIH-630), a Dopamine D2 receptor antagonist. . CAS #: 129722-12-9. Molecular Formula: C23H27Cl2N3O2. Molecular Weight: 448.4 g/mol.</p>

Chemical structure of Aripiprazole (SIH-630), a Dopamine D2 receptor antagonist. . CAS #: 129722-12-9. Molecular Formula: C23H27Cl2N3O2. Molecular Weight: 448.4 g/mol.

Reviews

Reviews

There are no reviews yet.

Be the first to review “Aripiprazole”

Your email address will not be published. Required fields are marked *