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| Product Name | D-AP5.Na |
| Description |
NMDA receptor antagonist |
| Purity | >99.5 |
| CAS No. | 14375-45-2 |
| Molecular Formula | C5H12NO5P.Na |
| Molecular Weight | 219.11 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Antagonist |
| Solubility | Soluble in 1 M NH4OH (50 mg/ml); water (9 mg/ml). |
| Source | Synthetic |
| Appearance | White solid |
| SMILES | [C@@H]([NH3+])(CCC[P]([O-])([O-])=O)C([O-])=O |
| Safety Phrases |
Classification: Not WHMIS controlled. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Cite This Product | D-AP5.Na (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-412) |
Biological Description
| Alternative Names | D-amino-5-phosphonopentaoic acid sodium salt |
| Research Areas | Glutamate Receptors, Ion Channels, Neuroscience, Neurotransmitter Receptors, NMDA Receptors |
| Scientific Background | D-AP5.Na (D-(-)-2-Amino-5-phosphonopentanoic acid sodium salt) is a selective NMDA receptor antagonist that inhibits glutamate binding at the receptor site. NMDA receptors are critical for synaptic plasticity, learning, and memory, but their overactivation leads to excitotoxicity—a major contributor to neuronal death in neurodegenerative diseases such as Alzheimer’s, Huntington’s, and ALS. D-AP5.Na is widely used in neuroscience to study NMDA receptor-mediated signaling and to explore neuroprotective strategies by blocking calcium influx and excitotoxic damage. Its sodium salt form enhances solubility and stability for in vitro and in vivo applications. |
| References |
1. Davies J., & Watkins J. (1982) Brain Res. 378-86. 2. Schulte M., Roon R., Chalmers D., Sunter D., & Koerner J. (1994) Brain Res. 203-7. |
Product Images
Chemical structure of D-AP5.Na (SIH-412), a Glutamate-NMDA receptor antagonist. CAS #: 14375-45-2. Molecular Formula: C5H12NO5P.Na. Molecular Weight: 219.11 g/mol.
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