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| Product Name | Montelukast |
| Description |
Leukotriene CysLT1 antagonist |
| Purity | >98% (HPLC); NMR (conforms) |
| CAS No. | 151767-02-1 |
| Molecular Formula | C35H35ClNO3S • Na |
| Molecular Weight | 608.2 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Antagonist |
| Solubility | Soluble in DMSO (50 mg/ml), or water (30 mg/ml), or ethanol (60 mg/ml) |
| Source | Synthetic |
| Appearance | Powder |
| SMILES | CC(C)(O)C(C=CC=C1)=C1CC[C@H](SCC2(CC2)CC([O-])=O)C3=CC(/C=C/C4=NC5=CC(Cl)=CC=C5C=C4)=CC=C3.[Na+] |
| InChI | 1S/C35H36ClNO3S.Na/c1-34(2,40)30-9-4-3-7-25(30)13-17-32(41-23-35(18-19-35)22-33(38)39)27-8-5-6-24(20-27)10-15-29-16-12-26-11-14-28(36)21-31(26)37-29;/h3-12,14-16,20-21,32,40H,13,17-19,22-23H2,1-2H3,( |
| InChIKey | LBFBRXGCXUHRJY-YBGTYPRZSA-M |
| Safety Phrases |
Classification: D2A Very Toxic Material Causing Other Toxic Effects - Reproductive hazard E Corrosive Material - Corrosive to skin Hazard statement(s): H318 Causes serious eye damage. H361fd Suspected of damaging fertility. Suspected of damaging the unborn child. Precautionary statement(s): P280 Wear protective gloves/ eye protection/ face protection. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
| Cite This Product | Montelukast sodium (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-538) |
Biological Description
| Alternative Names | 1-[[[(1R)-1-[3-(1E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]-methyl]-cyclopropaneacetic acid, monosodium salt, Montelukast sodium, Montelukast monosodium salt, MK-0476, MK-476, KS-1087 |
| Research Areas | Immunology, Innate Immunity, Macrophage |
| PubChem ID | 23663996 |
| Scientific Background | Montelukast sodium, a selective cysteinyl leukotriene receptor 1 (CysLT1) antagonist, is gaining attention in neuroscience for its neuroprotective and anti-inflammatory properties. Originally developed for asthma and allergic rhinitis, Montelukast has demonstrated the ability to cross the blood-brain barrier and modulate neuroinflammatory responses. In preclinical models, it has been shown to reduce blood-brain barrier disruption, inhibit leukocyte migration, and suppress seizure activity. These effects suggest potential therapeutic applications in neurodegenerative diseases such as Alzheimer's and Parkinson's, where inflammation and barrier dysfunction are key pathological features. |
Product Images
Chemical structure of Montelukast sodium (SIH-538), a Leukotriene CysLT1 antagonist. CAS #: 151767-02-1. Molecular Formula: C35H35ClNO3S • Na. Molecular Weight: 608.2 g/mol.
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