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| Product Name | Antibiotic A-23187 |
| Description |
Ca2+ ionophore |
| Purity | >98% |
| CAS No. | 52665-69-7 |
| Molecular Formula | C29H37N3O6 |
| Molecular Weight | 523.63 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inducer |
| Solubility | Soluble to 10 mM in ethanol and to 50 mM in DMSO |
| Source | Synthetic |
| Appearance | White Solid |
| SMILES | C[C@H]1CCC2([C@@H](C[C@H]([C@H](O2)C(C)C(=O)C3=CC=CN3)C)C)O[C@H]1CC4=NC5=C(O4)C=CC(=C5C(=O)O)NC |
| InChI | InChI=1S/C29H37N3O6/c1-15-10-11-29(17(3)13-16(2)27(38-29)18(4)26(33)20-7-6-12-31-20)37-22(15)14-23-32-25-21(36-23)9-8 |
| InChIKey | HIYAVKIYRIFSCZ-CVXKHCKVSA-N |
| Safety Phrases |
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection |
| Cite This Product | Antibiotic A-23187 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-227) |
Biological Description
| Alternative Names | 5-(Methylamino)-2-({(2S,3S,8S,9R,11R)-3,9,11-trimethyl-8-[(2S)-1-oxo-1-(1H-pyrrol-2-yl)-2-propanyl]-1,7-dioxaspiro[5.5]undec-2-yl}methyl)-1,3-benzoxazole-4-carboxylic acid, A23187, Calcimycin |
| Research Areas | Apoptosis, Cancer |
| PubChem ID | 40486 |
| Scientific Background | A23187 is a mobile ion-carrier that forms stable complexes with divalent cations. It has antibiotic properties against gram positive bacteria and funghi. It also acts as divalent cation ionophore, that is used to increase intracellular calcium levels in intact cells (1). It also induces apoptosis in some cells and prevents it in others (2). |
| References |
1. Abbott B.J., et al. (1979) Antimicrob Agents Chemother. 16(6): 808-812. 2. http://a23187.4mg.com |
Product Images
Chemical structure of Antibiotic A-23187 (SIH-227), a Ca2+ ionophore. CAS #: 52665-69-7. Molecular Formula: C29H37N3O6. Molecular Weight: 523.63 g/mol.
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