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| Product Name | Trolox |
| Description |
Water-Soluble Vitamin E Analog |
| Purity | >98% (TLC); NMR (Conforms) |
| CAS No. | 53188-07-1 |
| Molecular Formula | C14H18O4 |
| Molecular Weight | 250.3 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Antioxidant |
| Solubility | Soluble in DMSO (25 mg/ml); or ethanol (25 mg/ml); or water at alkaline pH |
| Source | Synthetic |
| Appearance | Off-white powder |
| SMILES | CC1=C(C(=C2CCC(OC2=C1C)(C)C(=O)O)C)O |
| InChI | InChI=1S/C14H18O4/c1-7-8(2)12-10(9(3)11(7)15)5-6-14(4,18-12)13(16)17/h15H,5-6H2,1-4H3,(H,16,17) |
| InChIKey | GLEVLJDDWXEYCO-UHFFFAOYSA-N |
| Safety Phrases |
WHMIS Classification: D2B Toxic Material Causing Other Toxic Effects. Moderate skin irritant. Moderate respiratory irritant. Moderate eye irritant. GHS Classification Acute toxicity, Oral (Category 5) Skin corrosion/irritation (Category 2) Serious eye damage/eye irritation (Category 2A) Specific target organ toxicity - single exposure (Category 3), Respiratory system Signal word: Warning Hazard statement(s): H303 May be harmful if swallowed. H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation. Precautionary statement(s): P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. HMIS Classification: Health hazard: 2 Flammability: 0 Physical hazards: 0 Potential Health Effects: Inhalation - May be harmful if inhaled. May cause respiratory tract irritation. Skin - May be harmful if absorbed through skin. May cause skin irritation. Eyes - May cause eye irritation. Ingestion - May be harmful if swallowed. |
| Cite This Product | Trolox (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-556) |
Biological Description
| Alternative Names | (±)-6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid, 6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid; TROLOX C; 3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid; 2H-1-Benzopyran-2-carboxylic acid, 6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromene-2-carboxylic acid |
| Research Areas | Alzheimer's Disease, Atherosclerosis, Cancer, Cardiovascular System, Cell Signaling, Diabetes Associated, Neurodegeneration, Neuroscience, Oxidative Stress |
| PubChem ID | 40634 |
| Scientific Background | Trolox is a water-soluble analog of vitamin E (α-tocopherol) with potent antioxidant properties. In neurodegenerative disease research, Trolox is widely used to study oxidative stress, a key contributor to neuronal damage in conditions such as Alzheimer’s, Parkinson’s, and Huntington’s disease. Trolox scavenges reactive oxygen species (ROS) and protects against lipid peroxidation, mitochondrial dysfunction, and DNA damage. Its ability to cross cell membranes and neutralize oxidative insults makes it a valuable tool for evaluating neuroprotective strategies and antioxidant therapies in both in vitro and in vivo models of neurodegeneration. |
Product Images
Chemical structure of Trolox (SIH-556), a Antioxidant vitamin E derivative. CAS #: 53188-07-1. Molecular Formula: C14H18O4. Molecular Weight: 250.3 g/mol.
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