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| Product Name | CBA |
| Description |
TRPM4 channel blocker |
| Purity | >98% (TLC); NMR (Conforms) |
| CAS No. | 351424-20-9 |
| Molecular Formula | C15H11Cl2NO4 |
| Molecular Weight | 340.2 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Blocker |
| Solubility | May be dissolved in DMSO (35 mg/ml) |
| Source | Synthetic |
| Appearance | Off-white powder |
| SMILES | C1=CC=C(C(=C1)OCC(=O)NC2=C(C=CC(=C2)Cl)C(=O)O)Cl |
| InChI | InChI=1S/C15H11Cl2NO4/c16-9-5-6-10(15(20)21)12(7-9)18-14(19)8-22-13-4-2-1-3-11(13)17/h1-7H,8H2,(H,18,19)(H,20,21) |
| InChIKey | CVQCJPCMPGKEDH-UHFFFAOYSA-N |
| Safety Phrases | Not a hazardous substance or mixture. |
| Cite This Product | CBA (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-633) |
Biological Description
| Alternative Names | 4-Chloro-2-[[2-(2-chlorophenoxy)acetyl]amino]benzoic acid; TRPM4-IN-5 |
| Research Areas | Ion Channels, Neuroscience, Neurotransmission, Transient Receptor Potential (TRP) Channels |
| PubChem ID | 2264067 |
| Scientific Background | CBA is a selective blocker of TRPM4 channels (IC50 = 1.5 µM), with no activity at related TRP channels or other ion channels. It has demonstrated neuroprotective effects in models of glutamate-induced neuronal degeneration and experimental autoimmune encephalomyelitis, a model of multiple sclerosis. By modulating TRPM4 activity, CBA provides a valuable tool for investigating calcium-independent cation flux in neurons and glial cells, and its role in neuroinflammation and neurodegeneration. Its specificity and in vivo efficacy make it a promising candidate for therapeutic exploration in CNS disorders. |
| References |
1.,LC Ozhathil et al. Br. J. Pharmacol. 2018 175:2504 2.,B Bianchi et al. Mol. Brain 2018 11:41 3.,A Borgstrom et al. J. Mol. Biol. 2021 433:166665 4.,G Diszhazi et al. J. Biol. Chem. 2021 297:101015 |
Product Images
Chemical structure of CBA (SIH-633), a TRPM4 channel blocker. CAS #: 351424-20-9. Molecular Formula: C15H11Cl2NO4. Molecular Weight: 340.2 g/mol.
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