Discovery through Partnership | Excellence through Quality
| Product Name | AICAR |
| Description |
Autophagy inducer |
| Purity | >99% (TLC), NMR conforms |
| CAS No. | 2627-69-2 |
| Molecular Formula | C9H14N4O5 |
| Molecular Weight | 258.2 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inducer |
| Solubility | Soluble to 75 mM in water and to 75 mM in DMSO. |
| Source | Synthetic |
| Appearance | Off-white solid. |
| SMILES | [C@@H]2([N]1C(=C(C(N)=O)N=C1)N)O[C@H](CO)[C@H]([C@H]2O)O |
| InChI | InChI=1S/C9H14N4O5/c10-7-4(8(11)17)12-2-13(7)9-6(16)5(15)3(1-14)18-9/h2-3,5-6,9,14-16H,1,10H2,(H2,11,17)/t3-,5-,6-,9-/m1/s1 |
| InChIKey | RTRQQBHATOEIAF-UUOKFMHZSA-N |
| Safety Phrases |
Classification: D2B- Toxic Material Causing Other Toxic Effects, Moderate skin irritant, Moderate respiratory irritant, Moderate eye irritant Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H315- Causes skin irritation. H319- Causes serious eye irritation. H335- May cause respiratory irritation. Precautionary statements: P261- Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P264- Wash skin thoroughly after handling. P271- Use only outdoors or in a well-ventilated area. P280- Wear protective gloves/ eye protection/ face protection. P302 + P352- IF ON SKIN: Wash with plenty of soap and water. P304 + P340- IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338- IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312- Call a POISON CENTER or doctor/ physician if you feel unwell. P321- Specific treatment (see supplemental first aid instructions on this label). P332 + P313- If skin irritation occurs: Get medical advice/ attention. P337 + P313- If eye irritation persists: Get medical advice/ attention. P362- Take off contaminated clothing and wash before reuse. P403 + P233- Store in a well-ventilated place. Keep container tightly closed. P405- Store locked up. P501- Dispose of contents/ container to an approved waste disposal plant. |
| Cite This Product | AICAR (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-402) |
Biological Description
| Alternative Names | N1-(β-D-Ribofuranosyl)-5-aminoimidazole-4-carboxamide |
| Research Areas | Autophagy, Cancer |
| PubChem ID | 17513 |
| Scientific Background | AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide) is an adenosine analog that activates AMP-activated protein kinase (AMPK) upon intracellular conversion to ZMP. AMPK is a master regulator of cellular energy homeostasis and plays a pivotal role in modulating autophagy, mitochondrial biogenesis, and oxidative stress responses. In the context of neurodegenerative disease research, AICAR is of particular interest due to its ability to induce autophagy through AMPK-mediated phosphorylation of ULK1, bypassing mTORC1 inhibition. This mechanism is critical in clearing misfolded proteins and damaged organelles, processes that are impaired in disorders such as Alzheimer’s, Parkinson’s, and Huntington’s disease. AICAR’s neuroprotective potential is further supported by its capacity to enhance neuronal survival under metabolic stress, making it a valuable tool for studying energy metabolism and therapeutic strategies in neurodegeneration. |
| References |
1. Jhun B.S., et al. (2004) Biochem Biophys Res Commun. 318(2): 372-80. 2. Huang H., et al. (2013) Autophagy. 9(2): 175-95. |
Product Images
Chemical structure of AICAR (SIH-402), a Autophagy inducer. CAS #: 2627-69-2 . Molecular Formula: C9H14N4O5. Molecular Weight: 258.2 g/mol.
Powered by Bioz
Reviews
There are no reviews yet.