Deguelin

Akt inhibitor

Catalog No. SIH-251

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CAS No. 522-17-8
Molecular Formula C23H22O6
SKU: SIH-251 Categories: ,

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SIH-251_Deguelin_Chemical_Structure.png
Product Name Deguelin
Description

Akt inhibitor

Purity >98%
CAS No. 522-17-8
Molecular Formula C23H22O6
Molecular Weight 394.42
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inducer
Solubility Soluble to 50 mM in ethanol and to 100 mM in DMSO
Source Synthetic
Appearance Cream Solid
SMILES CC1(C=CC2=C(O1)C=CC3=C2O[C@@H]4COC5=CC(=C(C=C5[C@@H]4C3=O)OC)OC)C
InChI InChI=1S/C23H22O6/c1-23(2)8-7-12-15(29-23)6-5-13-21(24)20-14-9-17(25-3)18(26-4)10-16(14)27-11-19(20)28-22(12)13/h5-10,19-20H
InChIKey ORDAZKGHSNRHTD-UXHICEINSA-N
Safety Phrases Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Cite This Product Deguelin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-251)

Biological Description

Alternative Names (7aS,13aS)-9,10-Dimethoxy-3,3-dimethyl-13,13a-dihydro-3H-chromeno[3,4-b]pyrano[2,3-h]chromen-7(7aH)-one
Research Areas Apoptosis, Cancer
PubChem ID 107935
Scientific Background Deguelin is a rotenoid compound with notable anti-cancer and neurotoxic properties. It inhibits mitochondrial complex I, leading to increased oxidative stress and apoptosis in cancer cells. However, its neurotoxicity has raised concerns, particularly due to its association with Parkinsonian symptoms in animal models. Deguelin's dual role as a therapeutic agent and neurotoxin makes it a compound of interest in neurodegenerative disease research, especially for understanding mitochondrial dysfunction and oxidative stress pathways in dopaminergic neurons.
References 1. Lee H.Y. (2004) Biochem Pharmacol. 68(6): 1119-1124.
2. Caboni P., et al. (2004) Chem Res. Toxicol. 17(11): 1540-1548.

Product Images

<p>Chemical structure of Deguelin (SIH-251), a Akt inhibitor. CAS #: 522-17-8. Molecular Formula: C23H22O6. Molecular Weight: 394.42 g/mol.</p>

Chemical structure of Deguelin (SIH-251), a Akt inhibitor. CAS #: 522-17-8. Molecular Formula: C23H22O6. Molecular Weight: 394.42 g/mol.

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