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| Product Name | Deguelin |
| Description |
Akt inhibitor |
| Purity | >98% |
| CAS No. | 522-17-8 |
| Molecular Formula | C23H22O6 |
| Molecular Weight | 394.42 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inducer |
| Solubility | Soluble to 50 mM in ethanol and to 100 mM in DMSO |
| Source | Synthetic |
| Appearance | Cream Solid |
| SMILES | CC1(C=CC2=C(O1)C=CC3=C2O[C@@H]4COC5=CC(=C(C=C5[C@@H]4C3=O)OC)OC)C |
| InChI | InChI=1S/C23H22O6/c1-23(2)8-7-12-15(29-23)6-5-13-21(24)20-14-9-17(25-3)18(26-4)10-16(14)27-11-19(20)28-22(12)13/h5-10,19-20H |
| InChIKey | ORDAZKGHSNRHTD-UXHICEINSA-N |
| Safety Phrases |
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection |
| Cite This Product | Deguelin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-251) |
Biological Description
| Alternative Names | (7aS,13aS)-9,10-Dimethoxy-3,3-dimethyl-13,13a-dihydro-3H-chromeno[3,4-b]pyrano[2,3-h]chromen-7(7aH)-one |
| Research Areas | Apoptosis, Cancer |
| PubChem ID | 107935 |
| Scientific Background | Deguelin is a rotenoid compound with notable anti-cancer and neurotoxic properties. It inhibits mitochondrial complex I, leading to increased oxidative stress and apoptosis in cancer cells. However, its neurotoxicity has raised concerns, particularly due to its association with Parkinsonian symptoms in animal models. Deguelin's dual role as a therapeutic agent and neurotoxin makes it a compound of interest in neurodegenerative disease research, especially for understanding mitochondrial dysfunction and oxidative stress pathways in dopaminergic neurons. |
| References |
1. Lee H.Y. (2004) Biochem Pharmacol. 68(6): 1119-1124. 2. Caboni P., et al. (2004) Chem Res. Toxicol. 17(11): 1540-1548. |
Product Images
Chemical structure of Deguelin (SIH-251), a Akt inhibitor. CAS #: 522-17-8. Molecular Formula: C23H22O6. Molecular Weight: 394.42 g/mol.
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