Irinotecan HCl

Topoisomerase I inhibitor

Catalog No. SIH-243

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CAS No. 100286-90-6
Molecular Formula C33H38N4O6•HCl
SKU: SIH-243 Categories: ,

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SIH-243_Irinotecan_HCl_Chemical_Structure.png
Product Name Irinotecan HCl
Description

Topoisomerase I inhibitor

Purity >98%
CAS No. 100286-90-6
Molecular Formula C33H38N4O6•HCl
Molecular Weight 623.14
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inducer
Solubility Soluble to 50 mg/ml in DMSO
Source Synthetic
Appearance Yellow solid
SMILES CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)[C@@]4(CC)O)C2=NC5=C1C=C(C=C5)OC(=O)N6CCC(CC6)N7CCCCC7
InChI InChI=1S/C33H38N4O6/c1-3-22-23-16-21(43-32(40)36-14-10-20(11-15-36)35-12-6-5-7-13-35)8-9-27(23)34-29-24(22)18-37-28(29)1
InChIKey UWKQSNNFCGGAFS-XIFFEERXSA-N
Safety Phrases Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible)
Risk Phrases:
R20/21/22 - Harmful by inhilation, in contact with skin and if swallowed
R62 - Possible risk of impaired fertility
R68 - Possible risk of irreversible effects
Hazard Phrases:
H302
Cite This Product Irinotecan HCl (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-243)

Biological Description

Alternative Names (4S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl 1,4'-bipiperidine-1'-carboxylate, CPT11, Camptothecin 11
Research Areas Apoptosis, Cancer
PubChem ID 74990
Scientific Background Irinotecan is a semisynthetic analogue of camptothecin that inhibits topoisomerase I. It is converted to its active metabolite SN-38, which interferes with DNA replication and transcription. In neurobiology, irinotecan is used to study DNA damage responses and has potential applications in understanding neuronal vulnerability to genotoxic stress.
References 1. Innocentri F., et al. (2004) J Clin. Oncol. 22(8): 1382-1388.
2. O’Dwyer P.J., and Catalano R.B. (2006) J Clin Oncol. 24(28): 4534-4538.

Product Images

<p>Chemical structure of Irinotecan HCl (SIH-243), a Topoisomerase I inhibitor. CAS #: 100286-90-6. Molecular Formula: C33H38N4O6.HCl. Molecular Weight: 623.14 g/mol.</p>

Chemical structure of Irinotecan HCl (SIH-243), a Topoisomerase I inhibitor. CAS #: 100286-90-6. Molecular Formula: C33H38N4O6.HCl. Molecular Weight: 623.14 g/mol.

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