Metformin Hydrochloride

Autophagy inducer

Catalog No. SIH-395

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CAS No. 1115-70-4
Molecular Formula C4H11N5•HCl
SKU: SIH-395 Categories: ,

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SIH-395_Metformin_Chemical_Structure.png
Product Name Metformin Hydrochloride
Description

Autophagy inducer

Purity >97%
CAS No. 1115-70-4
Molecular Formula C4H11N5•HCl
Molecular Weight 165.6
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inducer
Solubility Soluble to 100 mM in water and to 50 mM in DMSO.
Source Synthetic
Appearance White crystalline powder.
SMILES [H+].CN(C)C(N=C(N)N)=N.[Cl-]
InChI InChI=1S/C4H11N5.ClH/c1-9(2)4(7)8-3(5)6;/h1-2H3,(H5,5,6,7,8);1H
InChIKey OETHQSJEHLVLGH-UHFFFAOYSA-N
Safety Phrases Classification: D2B- Toxic Material Causing Other Toxic Effects, Moderate skin irritant, Moderate eye irritant
Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H302- Harmful if swallowed.
H315- Causes skin irritation.
H319- Causes serious eye irritation.
Precautionary statements:
P305 + P351 + P338- IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Cite This Product Metformin Hydrochloride (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-395)

Biological Description

Alternative Names N,N-Dimethylimidodicarbonimidic diamide hydrochloride
Research Areas Autophagy, Cancer
PubChem ID 14219
Scientific Background Metformin Hydrochloride is a widely used antidiabetic agent that improves insulin sensitivity and lowers blood glucose levels. In neuroscience, Metformin has emerged as a promising neuroprotective compound. It activates the LKB1-AMPK pathway, which inhibits mTORC1 and promotes autophagy—a key mechanism for clearing misfolded proteins and damaged organelles in neurons. Metformin has been shown to reduce alpha-synuclein phosphorylation and aggregation, making it relevant in Parkinson’s disease research. It also exhibits anti-inflammatory and antioxidant effects, contributing to its potential in Alzheimer’s disease and other neurodegenerative conditions. Metformin’s ability to modulate energy metabolism and cellular stress responses positions it as a candidate for therapeutic repurposing in brain aging and neurodegeneration.
References 1. Kirpichnikov D., et al. (2002). Ann Intern Med. 137(1): 25-33.
2. Caton P. W., et al. (2010). J Endocrino;. 205(1): 97-106.
3. Feng Y. H., et al. (2011). J Cell Mol Med. 15(4): 825-36.
4. Huang H., et al. (2013). Autophagy. 9(2): 175-95.

Product Images

<p>Chemical structure of Metformin Hydrochloride (SIH-395), a Autophagy inducer. CAS #: 1115-70-4. Molecular Formula: C4H11N5 . HCl. Molecular Weight: 165.6 g/mol.</p>

Chemical structure of Metformin Hydrochloride (SIH-395), a Autophagy inducer. CAS #: 1115-70-4. Molecular Formula: C4H11N5 . HCl. Molecular Weight: 165.6 g/mol.

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