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| Product Name | Nigericin |
| Description |
NALP3 activator |
| Purity | >98% |
| CAS No. | 28643-80-3 |
| Molecular Formula | C40H67NaO11 |
| Molecular Weight | 746.94 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inducer |
| Solubility | Soluble to 50 mM in DMSO and 20 mM in ethanol |
| Source | Synthetic |
| Appearance | White to off-white Solid |
| SMILES | C[C@H]1CC[C@@H](O[C@H]1[C@@H](C)C(=O)O)C[C@@H]2C[C@H]([C@H]([C@@]3(O2)[C@@H](C[C@@](O3)(C)[C@H]4CC[C@@](O4)(C)[C@H]5[C@H](C[C@@H](O5)[C@@H]6[C@H](C[C@H]([C@@](O6)(CO)O)C)C)C)C)C)OC |
| InChI | InChI=1S/C40H68O11/c1-21-11-12-28(46-33(21)26(6)36(42)43)17-29-18-30(45-10)27(7)40(48-29)25(5)19-38(9,51-40)32-13-14-37(8,49-32)35-23(3)16-3 |
| InChIKey | DANUORFCFTYTSZ-SJSJOXFOSA-N |
| Safety Phrases |
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Hazard Phrases: H302 |
| Cite This Product | Nigericin (StressMarq Biosciences, Canada, Cat # SIH-229) |
Biological Description
| Alternative Names | (2R)-2-[(2R,3S,6R)-6-{[(2S,4R,5R,7R,9R,10R)-2-{(2S,2'R,3'S,5R,5'R)-5'-[(2S,3S,5R,6R)-6-Hydroxy-6-(hydroxymethyl)-3,5-dimethyltetrahydro-2H-pyran-2-yl]-2,3'-dimethyloctahydro-2,2'-bifuran-5-yl}-9-metho xy-2,4,10-trimethyl-1,6-dioxaspiro[4.5]dec-7-yl]methyl}-3-methyltetrahydro-2H-pyran-2-yl]propanoic acid |
| Research Areas | Apoptosis, Cancer |
| PubChem ID | 23681158 |
| Scientific Background | Nigericin is a potassium and sodium ionophore that disrupts mitochondrial membrane potential and stimulates calcium release from mitochondrial stores. In neuroscience, it is used to study mitochondrial dysfunction, a hallmark of many neurodegenerative diseases. By altering ion gradients, nigericin helps elucidate the role of mitochondrial signaling and bioenergetics in neuronal health and disease. |
| References |
1. Vercesi A.E., et al. (1993) J Biol Chem. 268: 8564. 2. Graven S.N., Estrada-O, S., Lardy H.A. (1966) Proc Natl Acad Sci USA. 56(2): 654-658. |
Product Images
Chemical structure of Nigericin (SIH-229), a Induces rapid intracellular acidification. CAS #: 28643-80-3. Molecular Formula: C40H67NaO11. Molecular Weight: 746.94 g/mol.
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