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| Product Name | Piperlongumine |
| Description |
Apoptosis Inducer |
| Purity | >98% |
| CAS No. | 20069-09-4 |
| Molecular Formula | C17H19NO5 |
| Molecular Weight | 317.3 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inducer |
| Solubility | Soluble in 25 mg/ml DMSO |
| Source | Synthetic |
| Appearance | Cream Solid |
| SMILES | COC1=CC(=CC(=C1OC)OC)/C=C/C(=O)N2CCC=CC2=O |
| InChI | InChI=1S/C17H19NO5/c1-21-13-10-12(11-14(22-2)17(13)23-3)7-8-16(20)18-9-5-4-6-15(18)19/h4,6-8,10-11H,5,9H2,1-3H3 |
| InChIKey | VABYUUZNAVQNPG-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Hazard Phrases: H302 |
| Cite This Product | Piperlongumine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-156) |
Biological Description
| Alternative Names | 1-[(2E)-3-(3,4,5-Trimethoxyphenyl)-2-propenoyl]-5,6-dihydro-2(1H)-pyridinone |
| Research Areas | Cancer, Oxidative Stress |
| PubChem ID | 637858 |
| Scientific Background | Piperlongumine is a naturally derived compound known for its selective cytotoxicity against cancer cells by disrupting their oxidative stress response. In neuroscience, its relevance lies in its ability to modulate reactive oxygen species (ROS), which are implicated in neurodegenerative processes. By inhibiting platelet aggregation induced by specific stimuli and sparing normal cells, Piperlongumine offers a potential therapeutic avenue for neuroinflammation and oxidative stress-related neuronal damage. Its antioxidant modulation may contribute to neuroprotection in disorders such as Alzheimer's and Parkinson's disease. |
| References |
1. Park B.S., et al. (2008) Phytother Res. 22(9): 1195-1199. 2. Raj L., et al. (2011) Nature. 475(7355): 231. |
Product Images
Chemical structure of Piperlongumine (SIH-156), a Apoptosis inducer in oxidative stressed cells. CAS #: 20069-09-4. Molecular Formula: C17H19NO5. Molecular Weight: 317.3 g/mol.
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