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| Product Name | R(-)-Gossypol |
| Description |
Bcl-2 inhibitor |
| Purity | >98% |
| CAS No. | 303-45-7 |
| Molecular Formula | C30H30O8 |
| Molecular Weight | 518.56 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inducer |
| Solubility | Soluble to 25 mM in ethanol and in DMSO. |
| Source | Synthetic |
| Appearance | Dark Yellow Solid |
| SMILES | CC1=CC2=C(C(=C(C(=C2C(C)C)O)O)C=O)C(=C1C3=C(C4=C(C=C3C)C(=C(C(=C4C=O)O)O)C(C)C)O)O |
| InChI | InChI=1S/C30H30O8/c1-11(2)19-15-7-13(5)21(27(35)23(15)17(9-31)25(33)29(19)37)22-14(6)8-16-20(12(3)4)30(38)26(34)18(10-32)24(16)28(2 |
| InChIKey | QBKSWRVVCFFDOT-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R62- Possible risk of impaired fertility R68- Possible risk of irreversible effects Hazard Phrases: H351 Precautionary Phrases: P281 |
| Cite This Product | R(-)-Gossypol (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-223) |
Biological Description
| Alternative Names | 1,1',6,6',7,7'-Hexahydroxy-5,5'-diisopropyl-3,3'-dimethyl-2,2'-binaphthalene-8,8'-dicarbaldehyde, Gossypol |
| Research Areas | Apoptosis, Cancer |
| PubChem ID | 3503 |
| Scientific Background | R(-)-Gossypol is a natural phenolic compound derived from the cotton plant, known for its pro-apoptotic and enzyme-inhibitory properties. In neuroscience, it has been studied for its ability to modulate apoptotic pathways through regulation of Bcl-2 family proteins and inhibition of calcineurin. These mechanisms are relevant to neurodegenerative diseases characterized by dysregulated cell death and calcium signaling. |
| References |
1. www.bioscreening.net “Gossypol” 2. Carruthers N.J., Dowd M.K., and Stemmer P.M. (2007) Eur J Pharmacol. 555(2-3): 106-114. |
Product Images
Chemical structure of R(-)-Gossypol (SIH-223), a Bcl-2 inhibitor. CAS #: 303-45-7. Molecular Formula: C30H30O8. Molecular Weight: 518.56 g/mol.
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