Rottlerin

Autophagy inducer

Catalog No. SIH-394

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CAS No. 82-08-6
Molecular Formula C30H28O8
SKU: SIH-394 Categories: ,

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SIH-394_Rottlerin_Chemical_Structure.png
Product Name Rottlerin
Description

Autophagy inducer

Purity >98%
CAS No. 82-08-6
Molecular Formula C30H28O8
Molecular Weight 516.55
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inducer
Solubility Soluble to 2 mM in ethanol and to 20 mM in DMSO.
Source Synthetic
Appearance Orange to brown solid.
SMILES C1=CC=CC=C1/C=C/C(C2=C(C(=C(C3=C2OC(C)(C)C=C3)O)CC4=C(C(=C(C(=C4O)C(C)=O)O)C)O)O)=O
InChI InChI=1S/C30H28O8/c1-15-24(33)19(27(36)22(16(2)31)25(15)34)14-20-26(35)18-12-13-30(3,4)38-29(18)23(28(20)37)21(32)11-10-17-8-6-5-7-9-17/h5-13,33-37H,14H2,1-4H3/b11-10+
InChIKey DEZFNHCVIZBHBI-ZHACJKMWSA-N
Safety Phrases Classification: Not WHMIS controlled.
Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product Rottlerin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-394)

Biological Description

Alternative Names 3'-[(8-Cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)methyl]-2',4',6'-trihydroxy-5'-methylacetophenone
Research Areas Autophagy, Cancer
PubChem ID 5281847
Scientific Background Rottlerin is a natural polyphenol known for its inhibitory effects on protein kinase C (PKC) and Ca²⁺/calmodulin-dependent kinase III. In neuroscience, Rottlerin is recognized for its neuroprotective properties, particularly in models of Parkinson’s disease. It acts as a mitochondrial uncoupler, depolarizing membrane potential and influencing energy metabolism. Rottlerin also induces autophagy by inhibiting mTORC1 signaling, a pathway critical for neuronal survival and protein clearance. Its ability to modulate potassium channels and reduce oxidative stress further supports its application in neurodegenerative disease research. Rottlerin is frequently used to explore the interplay between mitochondrial function, autophagy, and neuronal health.
References 1. Gschwendt M. et al. (1994) Biochem Biophys Res Commun. 199(1): 93-8.
2. Wu S., et al. (2007) J Cell Physiol. 210(3): 655-66.
3. Soltoff S. (2001) J Biol Chem. 276(41): 37986-92.
4. Balgi A., et al. (2009) PLoS One. 4(9): e7124.

Product Images

<p>Chemical structure of Rottlerin (SIH-394), a Autophagy inducer. CAS #: 82-08-6. Molecular Formula: C30H28O8. Molecular Weight: 516.55 g/mol.</p>

Chemical structure of Rottlerin (SIH-394), a Autophagy inducer. CAS #: 82-08-6. Molecular Formula: C30H28O8. Molecular Weight: 516.55 g/mol.

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