Sulindac Sulfone

Sulindac metabolite

Catalog No. SIH-262

0 out of 5 based on 0 customer ratings
CAS No. 59864-04-9
Molecular Formula C20H17FO4S
SKU: SIH-262 Categories: ,

Clear
SIH-262_Sulindac_Sulfone_Chemical_Structure.png
Product Name Sulindac Sulfone
Description

Sulindac metabolite

Purity >98%
CAS No. 59864-04-9
Molecular Formula C20H17FO4S
Molecular Weight 372.41
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inducer
Solubility Soluble to 25 mM in DMSO, 3 mM in ethanol
Source Synthetic
Appearance Yellow solid
SMILES CC1=C(C2=C(/C1=CC3=CC=C(C=C3)S(=O)(=O)C)C=CC(=C2)F)CC(=O)O
InChI InChI=1S/C20H17FO4S/c1-12-17(9-13-3-6-15(7-4-13)26(2,24)25)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9-
InChIKey MVGSNCBCUWPVDA-MFOYZWKCSA-N
Safety Phrases Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Cite This Product Sulindac Sulfone (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-262)

Biological Description

Alternative Names {(1Z)-5-Fluoro-2-methyl-1-[4-(methylsulfonyl)benzylidene]-1H-inden-3-yl}acetic acid
Research Areas Apoptosis, Cancer
PubChem ID 5472495
Scientific Background Sulindac sulfone is a non-COX-inhibiting metabolite of sulindac that retains anti-inflammatory and pro-apoptotic properties. Unlike sulindac sulfide, it does not inhibit prostaglandin synthesis but selectively induces apoptosis in abnormal cells. In neurodegenerative disease research, sulindac sulfone is being explored for its ability to modulate cell survival pathways and reduce neuroinflammation, offering a complementary mechanism of action to traditional NSAIDs.
References 1. Frahm S., et al. (2004) Cancer Cell Int. 4:4.
2. Piazza G.A., et al. (1997) Cancer Res. 57(12): 2452-2459.

Product Images

<p>Chemical structure of Sulindac Sulfone (SIH-262), a Modulates beta-catenin-mediated effects. CAS #: 59864-04-9. Molecular Formula: C20H17FO4S . Molecular Weight: 372.41 g/mol.</p>

Chemical structure of Sulindac Sulfone (SIH-262), a Modulates beta-catenin-mediated effects. CAS #: 59864-04-9. Molecular Formula: C20H17FO4S . Molecular Weight: 372.41 g/mol.

Reviews

Reviews

There are no reviews yet.

Be the first to review “Sulindac Sulfone”

Your email address will not be published. Required fields are marked *