Discovery through Partnership | Excellence through Quality
| Product Name | Sulindac Sulfone |
| Description |
Sulindac metabolite |
| Purity | >98% |
| CAS No. | 59864-04-9 |
| Molecular Formula | C20H17FO4S |
| Molecular Weight | 372.41 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inducer |
| Solubility | Soluble to 25 mM in DMSO, 3 mM in ethanol |
| Source | Synthetic |
| Appearance | Yellow solid |
| SMILES | CC1=C(C2=C(/C1=CC3=CC=C(C=C3)S(=O)(=O)C)C=CC(=C2)F)CC(=O)O |
| InChI | InChI=1S/C20H17FO4S/c1-12-17(9-13-3-6-15(7-4-13)26(2,24)25)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9- |
| InChIKey | MVGSNCBCUWPVDA-MFOYZWKCSA-N |
| Safety Phrases |
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection |
| Cite This Product | Sulindac Sulfone (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-262) |
Biological Description
| Alternative Names | {(1Z)-5-Fluoro-2-methyl-1-[4-(methylsulfonyl)benzylidene]-1H-inden-3-yl}acetic acid |
| Research Areas | Apoptosis, Cancer |
| PubChem ID | 5472495 |
| Scientific Background | Sulindac sulfone is a non-COX-inhibiting metabolite of sulindac that retains anti-inflammatory and pro-apoptotic properties. Unlike sulindac sulfide, it does not inhibit prostaglandin synthesis but selectively induces apoptosis in abnormal cells. In neurodegenerative disease research, sulindac sulfone is being explored for its ability to modulate cell survival pathways and reduce neuroinflammation, offering a complementary mechanism of action to traditional NSAIDs. |
| References |
1. Frahm S., et al. (2004) Cancer Cell Int. 4:4. 2. Piazza G.A., et al. (1997) Cancer Res. 57(12): 2452-2459. |
Product Images
Chemical structure of Sulindac Sulfone (SIH-262), a Modulates beta-catenin-mediated effects. CAS #: 59864-04-9. Molecular Formula: C20H17FO4S . Molecular Weight: 372.41 g/mol.
Powered by Bioz
Reviews
There are no reviews yet.