17-GMB-APA-GA

Hsp90 inhibitor

Catalog No. SIH-115

0 out of 5 based on 0 customer ratings
CAS No.
Molecular Formula C39H53N5O11
SKU: SIH-115 Categories: ,

Clear
SIH-115_17-GMB-APA-GA_Chemical_Structure.png
Product Name 17-GMB-APA-GA
Description

Hsp90 inhibitor

Purity >98%
Molecular Formula C39H53N5O11
Molecular Weight 767.9
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in DMSO (>25 mg/ml) and ethanol (10 mg/ml)
Source Synthetic
Appearance Purple Solid
SMILES O=C/1C2=C(/C(=O)C=C1NC(=O)C(=CC=C[C@H](OC)[C@@H](OC(=O)N)C(=C/[C@H](C)[C@@H](O)[C@@H](OC)C[C@H](C)C2)/C)C)NCCCNC(=O)CCCN3C(=O)C=C/C3=O
InChI InChI=1S/C39H53N5O11/c1-22-18-26-34(42-16-9-15-41-31(46)12-8-17-44-32(47)13-14-33(44)48)28(45)21-27(36(26)50)43-38(51)23(2)10-7-11-29(53-5)37(55-39(40)52)25(4)20-24(3)35(49)30(19-22)54-6/h7,10-11,13-
InChIKey OPWAYYOLUIAKCJ-DAJJPBRBSA-N
Safety Phrases Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Cite This Product 17-GMB-APA-GA (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-115)

Biological Description

Alternative Names [(3R,5S,6R,7S,10S,11S)-21-[3-[4-(2,5-dioxopyrrol-1-yl)butanoylamino]propylamino]-6-hydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
Research Areas Cancer, Heat Shock
PubChem ID 57370016
Scientific Background 17-GMB-APA-GA is a synthetic analog of geldanamycin engineered with a maleimido moiety, enabling its use in the development of immunoconjugates. While its primary application has been in targeted cancer therapies, its potential in neuroscience lies in its ability to selectively bind HSP90, a chaperone protein implicated in neurodegenerative disease pathways. By facilitating the targeted delivery of HSP90 inhibitors to specific cell types, 17-GMB-APA-GA may offer a novel strategy for modulating proteostasis in neural tissues. This targeted approach could enhance the clearance of misfolded proteins such as alpha-synuclein and tau, which are central to the pathology of Parkinson’s and Alzheimer’s diseases. Although further research is needed to validate its efficacy in neural models, 17-GMB-APA-GA represents a promising tool for precision medicine in neurodegeneration.
References 1. Mandler R., et al. (2004) Cancer Res. 64: 1460.
2. Mandler R., et al. (2002) Bioconj. Chem. 13: 786.
3. Mandler R., et al. (2000) J. Natl. Cancer Inst. 92: 1573.

Product Images

<p>Chemical structure of 17-GMB-APA-GA (SIH-115), a Hsp90 inhibitor. CAS #: N/A. Molecular Formula: C39H53N5O11. Molecular Weight: 767.9 g/mol.</p>

Chemical structure of 17-GMB-APA-GA (SIH-115), a Hsp90 inhibitor. CAS #: N/A. Molecular Formula: C39H53N5O11. Molecular Weight: 767.9 g/mol.

Reviews

Reviews

There are no reviews yet.

Be the first to review “17-GMB-APA-GA”

Your email address will not be published. Required fields are marked *