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| Product Name | A-967079 |
| Description |
TRPA1 blocker |
| Purity | >98% |
| CAS No. | 1170613-55-4 |
| Molecular Formula | C12H14FNO |
| Molecular Weight | 207.3 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO (25 mg/ml) |
| Source | Synthetic |
| Appearance | White solid |
| SMILES | CC/C(=NO)/C(=C/C1=CC=C(C=C1)F)/C |
| InChI | InChI=1S/C12H14FNO/c1-3-12(14-15)9(2)8-10-4-6-11(13)7-5-10/h4-8,15H,3H2,1-2H3/b9-8+,14-12+ |
| InChIKey | HKROEBDHHKMNBZ-CHBKHGQFSA-N |
| Safety Phrases |
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Hazard Phrases: H302-H315-H317-H318-H335 Precautionary Phrases: P261-P280-P305 + P351 + P338 |
| Cite This Product | A-967079 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-301) |
Biological Description
| Alternative Names | (1E,3E)-1-(4-Fluorophenyl)-N-hydroxy-2-methyl-1-penten-3-imine |
| Research Areas | Ion Channels, Neuroscience |
| PubChem ID | 42641861 |
| Scientific Background | A-967079 is a potent and selective antagonist of the TRPA1 ion channel, which is involved in pain and neuroinflammation. It exhibits high selectivity over other TRP channels and has a favorable pharmacokinetic profile. In neuroscience, A-967079 is used to study TRPA1-mediated sensory processing, neurogenic inflammation, and its potential role in neurodegenerative diseases involving oxidative stress and nociception. |
| References | 1. McGaraughty S., et al. (2010) Mol Pain. 6: 14. 2. Chen et al. (2011) PAIN. 152: 1165–1172. |
Product Images
Chemical structure of A-967079 (SIH-301), a TRPA1 blocker. CAS #: 1170613-55-4. Molecular Formula: C12H14FNO. Molecular Weight: 207.3 g/mol.
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Based on validation through cited publications.