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| Product Name | AG 1478 |
| Description |
EGFR kinase inhibitor |
| Purity | >98% (HPLC) |
| CAS No. | 153436-53-4 |
| Molecular Formula | C16H14ClN3O2 |
| Molecular Weight | 315.8 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO (10 mg/ml) |
| Source | Synthetic |
| Appearance | White to light yellow solid |
| SMILES | COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)Cl)OC |
| InChI | InChI=1S/C16H14ClN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20) |
| InChIKey | GFNNBHLJANVSQV-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Cite This Product | AG 1478 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-425) |
Biological Description
| Alternative Names | N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinamine, 4-(3-Chloroanilino)-6,7-dimethoxyquinazoline |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 2051 |
| Scientific Background | AG 1478 is a potent and selective inhibitor of EGFR. It does so by reducing EGF-stimulated DNA synthesis (seen in rat fibroblasts) and blocking EGF-dependent src-family kinase activation and p21/Cip 1/WAF1 induction (seen in A431 cells). AG 1478 is cell-permeable and active in vivo. |
| References |
1. Osherov N., & Levitzki A. (1994) Euro J. Biochem. 225(3): 1047–1053. 2. Miyazaki Y., et al. (1996) Biochem. Biophys. Research Comm. 226(2): 542–546. 3. Fan Z., et al. (1995) J Cell Biol. 131(1): 235–242. |
Product Images
Chemical structure of AG 1478 (SIH-425), a EGFR kinase inhibitor. CAS #: 175178-82-2. Molecular Formula: C16H14ClN3O2. Molecular Weight: 315.8 g/mol.
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