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| Product Name | AG-1296 |
| Description |
PDGFR kinase inhibitor |
| Purity | >98% (TLC) |
| CAS No. | 146535-11-7 |
| Molecular Formula | C16H14N2O2 |
| Molecular Weight | 266.3 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO or dichloromethane |
| Source | Synthetic |
| Appearance | Off-white to brownish solid |
| SMILES | C1=C(OC)C(=CC2=NC=C(N=C12)C3=CC=CC=C3)OC |
| InChI | InChI=1S/C16H14N2O2/c1-19-15-8-12-13(9-16(15)20-2)18-14(10-17-12)11-6-4-3-5-7-11/h3-10H,1-2H3 |
| InChIKey | QNOXYUNHIGOWNY-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Cite This Product | AG1296 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-426) |
Biological Description
| Alternative Names | Tyrphostin AG 1296, 6,7-Dimethoxy-3-phenylquinoxaline, 6,7-Dimethoxy-2-phenylquinoxaline |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 2049 |
| Scientific Background |
AG-1296 is a potent, cell-permeable inhibitor of platelet-derived growth factor receptor (PDGFR) tyrosine kinase, a key regulator of cellular proliferation, survival, and migration. While originally developed for oncology and vascular biology, AG-1296 has gained attention in neuroscience for its potential role in modulating neuroinflammation and glial cell activation—processes central to the progression of neurodegenerative diseases. PDGFR signaling is involved in the regulation of astrocytes and microglia, the primary immune cells of the central nervous system. Dysregulated PDGF signaling has been implicated in neuroinflammatory responses, blood-brain barrier dysfunction, and abnormal neuronal-glial interactions. By selectively inhibiting PDGFR, AG-1296 may attenuate these pathological processes, offering a mechanistic approach to reducing neuroinflammation and promoting neural tissue stability. Additionally, PDGF pathways are involved in neural development and repair, suggesting that AG-1296 could be used to study regenerative mechanisms in the brain. Its ability to penetrate cells and selectively block receptor activity makes it a valuable tool for dissecting the role of tyrosine kinase signaling in neurodegeneration, particularly in conditions such as Alzheimer’s disease, multiple sclerosis, and gliosis-related disorders. |
| References | 1. Strutz F., et al. (2001) Kidney Int. 59(2): 579–592. |
Product Images
Chemical structure of AG1296 (SIH-426), a PDGFR kinase inhibitor. CAS #: 146535-11-7. Molecular Formula: C16H14N2O2. Molecular Weight: 266.3 g/mol.
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