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| Product Name | Amlodipine |
| Description |
L-type Ca channel blocker |
| Purity | >98% |
| CAS No. | 111470-99-6 |
| Molecular Formula | C20H25ClN2O5•C6H5SO3H |
| Molecular Weight | 567.05 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble to 100 mM in DMSO and to 10 mM in water |
| Source | Synthetic |
| Appearance | White Solid |
| SMILES | CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN |
| InChI | InChI=1S/C20H25ClN2O5/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,23H,4,9-11 |
| InChIKey | HTIQEAQVCYTUBX-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R22 - Harmful if swallowed R62 - Possible risk of impaired fertility Hazard Phrases: H302-H315-H319-H335 Precautionary Phrases: P261-P305 + P351 + P338 |
| Cite This Product | Amlodipine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-315) |
Biological Description
| Alternative Names | 3-Ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydro-3,5-pyridinedicarboxylate, Norvasc |
| Research Areas | Calcium Channels, Ion Channels, Neuroscience, Voltage-Gated Calcium Channels |
| PubChem ID | 2162 |
| Scientific Background | Amlodipine is a long-acting calcium channel blocker used to treat hypertension and angina. In neuroscience, its effects on vascular smooth muscle and cerebral blood flow have been explored in models of stroke and neurovascular disorders. Amlodipine’s ability to reduce vascular resistance and improve perfusion may contribute to neuroprotection in ischemic conditions. Its pharmacological profile supports its use in studies of neurovascular regulation and cerebrovascular health. |
| References |
1. Luksa J., Josic D., Kremser M., Kopitar Z and Milutinovic S. (1997) J Chromatorgraphy. B, Biomed Sci and App. 693(2): 367-375. 2. Bahl V.K., Jadhav U.M., Thacker H.P. (2009) Am J Cardiovasc Drugs. 9(3): 135-142. |
Product Images
Chemical structure of Amlodipine (SIH-315), a L-type Ca channel blocker. CAS #: 111470-99-6. Molecular Formula: C20H25ClN2O5 · C6H5SO3H . Molecular Weight: 567.05 g/mol.
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