Advancing the Frontiers of Neurodegenerative Disease Research
| Product Name | Antimycin A Complex |
| Description |
Mitochondrial electron transport chain complex III inhibitor |
| Purity | >97% (TLC), NMR conforms |
| CAS No. | 1397-94-0 |
| Molecular Formula | C28H40N2O9 |
| Molecular Weight | 548.6 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | May be dissolved in DMSO (35 mg/ml); or ethanol (50 mg/ml) |
| Source | Synthetic |
| Appearance | White powder |
| SMILES | CCCCCC[C@@H]1[C@H]([C@@H](OC(=O)[C@H]([C@H](OC1=O)C)NC(=O)C2=C(C(=CC=C2)NC=O)O)C)OC(=O)CC(C)C |
| InChI | InChI=1S/C28H40N2O9/c1-6-7-8-9-11-20-25(39-22(32)14-16(2)3)18(5)38-28(36)23(17(4)37-27(20)35)30-26(34)19-12-10-13-21(24(19)33)29-15-31/h10,12-13,15-18,20,23,25,33H,6-9,11,14H2,1-5H3,(H,29,31)(H,30,34 |
| InChIKey | UIFFUZWRFRDZJC-SBOOETFBSA-N |
| Safety Phrases |
Classification: Danger , Hazard Statements: H300: Fatal if swallowed H400: Very toxic to aquatic life Precautionary Statements: P264, P270, P273, P301+P316, P321, P330, P391, P405, and P501 |
| Cite This Product | Antimycin A Complex (StressMarq Biosciences | Victoria, BC CANADA | Catalog# SIH-648) |
Biological Description
| Alternative Names | Antimycin A, Antipiricullin |
| Research Areas | Apoptosis, Neurodegeneration, Neuroscience |
| PubChem ID | 14957 |
| Scientific Background | Antimycin A is a potent inhibitor of mitochondrial electron transport chain (ETC) complex III that disrupts oxidative phosphorylation, reduces ATP production, and increases reactive oxygen species (ROS) generation (). Through the induction of mitochondrial dysfunction and oxidative stress, Antimycin A is widely used to model mechanisms associated with neurodegenerative diseases and other disorders characterized by impaired mitochondrial bioenergetics(2-6). When combined with oligomycin, Antimycin A also induces canonical PINK1-Parkin-dependent mitophagy in Parkin-overexpressing cells, providing a useful tool for studying mitochondrial quality control pathways(5). |
| References |
1. F.L. Muller et al. Biochemistry 2003, 42, 6493. 2. E.M. Choi. Inflammation 2012, 35, 1204. 3. B.J. Smith et al. J. Neurosci. 2023, 43, 2291. 4. A. Barzegari et al. Chem. Biol. Interact. 2022, 360, 109937. , 5. M Zachari et al. Dev. Cell 2019 50:627 6. N.M.C. Connolly et al. Cell Death Differ. 2018, 25, 542. |
Product Images
Chemical structure of Antimycin A Complex (SIH-648), a Mitochondrial electron transport chain complex III inhibitor. CAS #: 1397-94-0. Molecular Formula: C28H40N2O9. Molecular Weight: 548.6 g/mol.
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