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| Product Name | Aphidicolin |
| Description |
DNA polymerase inhibitor |
| Purity | >98% (TLC); NMR (Conforms) |
| CAS No. | 38966-21-1 |
| Molecular Formula | C20H34O4 |
| Molecular Weight | 338.5 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | May be dissolved in DMSO (10 mg/ml); or ethanol (1 mg/ml) |
| Source | Synthetic |
| Appearance | White powder |
| SMILES | C[C@]12CC[C@H]([C@@]([C@@H]1CC[C@@H]3[C@@]24CC[C@@]([C@H](C3)C4)(CO)O)(C)CO)O |
| InChI | InChI=1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1 |
| InChIKey | NOFOAYPPHIUXJR-APNQCZIXSA-N |
| Safety Phrases |
Classification: Caution: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection |
| Cite This Product | Aphidicolin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-605) |
Biological Description
| Alternative Names | (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-Tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-8,11a-methano-11aH-cyclohepta[a]naphthalene-4,9-dimethanol; (from Nigrospora sp.) |
| Research Areas | Cell Signaling, Epigenetics and Nuclear Signaling, Neuroscience |
| PubChem ID | 457964 |
| Scientific Background | Aphidicolin is a specific inhibitor of DNA polymerase α and δ, arresting cells in early S phase without affecting other polymerases. It is widely used in cell cycle studies and apoptosis research. In neuroscience, Aphidicolin is employed to investigate DNA replication stress, cell cycle regulation, and gene amplification in neural cells, contributing to the understanding of neurodegenerative mechanisms involving genomic instability. |
| References |
1.,Syvaoja J., et al. (1990) Proc. Natl. Acad. Sci. USA. 87(17):6664-6668. 2.,Urbani L., et al. (1995) Exp. Cell Res. 219(1):159-168. 3.,Kuwakado K., et al. (1993) Biochem. Pharmacol. 46:1909-1916. 4.,Yin D.X., and Schimke R.T. (1996) Proc. Natl. Acad. Sci. USA. 93:3394-3398. |
Product Images
Chemical structure of Aphidicolin (SIH-605), a DNA polymerase inhibitor. CAS #: 38966-21-1. Molecular Formula: C20H34O4. Molecular Weight: 338.5 g/mol.
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