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| Product Name | Borrelidin |
| Description |
Angiogenesis inhibitor |
| Purity | >98% (HPLC); NMR (conforms) |
| CAS No. | 7184-60-3 |
| Molecular Formula | C28H43NO6 |
| Molecular Weight | 489.7 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Blue Ice or 4ºC |
| Product Type | Inhibitor |
| Solubility | May be dissolved in DMSO or ethanol |
| Source | Fermentation from Streptomyces sp |
| Appearance | White crystalline powder |
| SMILES | CC1CC(C)CC(C)C(O)/C(=C/C=C/CC(OC(=O)CC(O)C(C)C1)C2CCCC2C(O)=O)C#N |
| InChI | InChI=1S/C28H43NO6/c1-17-12-18(2)14-20(4)27(32)21(16-29)8-5-6-11-25(22-9-7-10-23(22)28(33)34)35-26(31)15-24(30)19(3)13-17/h5-6,8,17-20,22-25,27,30,32H,7,9-15H2,1-4H3,(H,33,34)/b6-5+,21-8+ |
| InChIKey | InChIKey=OJCKRNPLOZHAOU-SLNPHPKOSA-N |
| Safety Phrases |
WHMIS Classification: Not WHMIS controlled. Not a dangerous substance according to GHS. HMIS Classification: Health hazard: 0 Flammability: 0 Physical hazards: 0 Potential Health Effects: Inhalation - May be harmful if inhaled. May cause respiratory tract irritation. Skin - May be harmful if absorbed through skin. May cause skin irritation. Eyes - May cause eye irritation. Ingestion - May be harmful if swallowed. |
| Cite This Product | Borrelidin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-546) |
Biological Description
| Alternative Names | 2-[(4E,6E)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxo-1-oxacyclooctadeca-4,6-dien-2-yl]cyclopentane-1-carboxylic acid, 2-[(4E,6E)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxo-1-oxacyclooctadeca-4,6-dien-2-yl]-1-cyclopentanecarboxylic acid 2-[(4E,6E)-7-cyano-8,16-dihydroxy-18-keto-9,11,13,15-tetramethyl-1-oxacyclooctadeca-4,6-dien-2-yl]cyclopentane-1-carboxylic acid, 7184-60-3, BORRELIDIN, Cyclopentanecarboxylic acid, 2-(7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl)-, Cyclopentanecarboxylic acid, 2-[(2S,4E,6Z,8R,9S,11R,13S,15S, 16S)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl]-, (1R,2R)-, NSC216128, Cyclopentanecarboxylic acid, 2-(7-cyano-8,16-dihydroxy-9,11, Cyclopentanecarboxylic acid, 2-[(2S,4E,6Z,8R,9S,11R,13S,15S, 16S)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl]-, (1R,2R)-, NSC271295, NSC277295, 2-[(4E,6E)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxo-1-oxacyclooctadeca-4,6-dien-2-yl]cyclopentane-1-carboxylic acid, Treponemycin |
| Research Areas | Angiogenesis, Apoptosis, Cancer, Cardiovascular System, Cell Signaling |
| PubChem ID | 6436801 |
| Scientific Background | Borrelidin is a macrolide antibiotic known for its potent inhibition of threonyl-tRNA synthetase, leading to disruption of protein synthesis. While its primary applications have been in antimicrobial and anticancer research, Borrelidin has also demonstrated anti-angiogenic and anti-inflammatory properties. These characteristics are increasingly relevant to neuroscience, particularly in the study of neurovascular integrity and neuroinflammation. By modulating angiogenesis and inflammatory signaling, Borrelidin may offer insights into the vascular contributions to neurodegenerative diseases. Its unique mechanism of action and broad bioactivity profile make it a valuable compound for exploring novel therapeutic pathways in both oncology and neurology. |
Product Images
Chemical structure of Borrelidin (SIH-546), a Angiogenesis inhibitor. CAS #: 7184-60-3. Molecular Formula: C28H43NO6. Molecular Weight: 489.7 g/mol.
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