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| Product Name | Bortezomib |
| Description |
Proteasome inhibitor |
| Purity | >98% |
| CAS No. | 179324-69-7 |
| Molecular Formula | C19H25BN4O4 |
| Molecular Weight | 384.2 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in 50 mg/ml DMSO, 35 mg/ml Ethanol |
| Source | Synthetic |
| Appearance | White Powder |
| SMILES | B([C@H](CC(C)C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O |
| InChI | InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m0/s1 |
| InChIKey | GXJABQQUPOEUTA-RDJZCZTQSA-N |
| Safety Phrases |
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes |
| Cite This Product | Bortezomib (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-328) |
Biological Description
| Alternative Names | B-[(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic Acid; [(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic Acid; Velcade; Radiciol; NSC 681239; DPBA; LDP 341; MG 341; mlN 341; NSC 681239; PS 314; PS 341; Radiciol; Velcade |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Proteasome Inhibitors |
| PubChem ID | 387447 |
| Scientific Background | Bortezomib is a potent and selective reversible inhibitor of the 20S proteasome. It blocks NFκB activation, inhibits tumor cell proliferation, and suppresses angiogenesis. In neuroscience, Bortezomib is used to study proteasome-mediated protein turnover and its role in neuroinflammation, synaptic remodeling, and neurodegenerative pathways such as those implicated in Alzheimer's and Parkinson's disease. |
| References |
1. Adams J., et al. (1999) Cancer Res. 59: 2615. 2. Williams S., et al. (2003) Mol. Cancer Ther. 2: 835. |
Product Images
Chemical structure of Bortezomib (SIH-328), a Proteasome inhibitor. CAS #: 179324-69-7. Molecular Formula: C19H25BN4O4. Molecular Weight: 384.2 g/mol.
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Based on validation through cited publications.