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| Product Name | Caffeic Acid Phenethyl Ester (CAPE) |
| Description |
NFkB Inhibitor |
| Purity | >98% |
| CAS No. | 104594-70-9 |
| Molecular Formula | C17H16O4 |
| Molecular Weight | 284.31 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble to 100 mM in DMSO, acetone, ethanol, methanol, acetonitrile |
| Source | Synthetic |
| Appearance | Off-White Solid |
| SMILES | C1=CC=C(C=C1)CCOC(=O)/C=C/C2=CC(=C(C=C2)O)O |
| InChI | InChI=1S/C17H16O4/c18-15-8-6-14(12-16(15)19)7-9-17(20)21-11-10-13-4-2-1-3-5-13/h1-9,12,18-19H,10-11H2/b9-7+ |
| InChIKey | SWUARLUWKZWEBQ-VQHVLOKHSA-N |
| Safety Phrases |
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Hazard Phrases: H315-H319-H335 Precautionary Phrases: P261-P305 + P351 + P338 |
| Cite This Product | CAPE (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-263) |
Biological Description
| Alternative Names | 2-Phenylethyl (2E)-3-(3,4-dihydroxyphenyl)acrylate, Caffeic acid phenethyl ester |
| Research Areas | Apoptosis, Cancer |
| PubChem ID | 5281787 |
| Scientific Background | Caffeic Acid Phenethyl Ester (CAPE) is a bioactive compound derived from propolis with potent antioxidant, anti-inflammatory, and neuroprotective properties. It inhibits NF-κB activation, suppresses lipid peroxidation, and modulates signaling pathways involved in cell survival and apoptosis. In neuroscience, CAPE has been studied for its ability to protect neurons from oxidative damage and inflammation, making it a promising candidate for therapeutic development in neurodegenerative diseases such as Parkinson’s and Alzheimer’s. |
| References | 1. Natarajan K., Singh S., Burke T.R., Grunberger D., Aggarwal B.B. (1996) Proc Natl Acad Sci USA. 93(17): 9090-9095. |
Product Images
Chemical structure of CAPE (SIH-263), a Inhibits NFkB activation. CAS #: 104594-70-9. Molecular Formula: C17H16O4. Molecular Weight: 284.31 g/mol.
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Based on validation through cited publications.