Product Name | Capsaicin |
Description |
TRPV1opener |
Purity | >60% (HPLC); NMR (conforms) |
CAS No. | 404-86-4 |
Molecular Formula | C18H27NO3 |
Molecular Weight | 305.41 |
Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Storage Temperature | -20ºC |
Shipping Temperature | Shipped Ambient |
Product Type | Small Molecules |
Solubility | Soluble in DMSO (20 mg/mL) and ethanol (15 mg/mL) |
Source | Synthetic |
Appearance | Off-White Solid |
SMILES | CC(C)/C=C/CCCCC(=O)NCC1=CC(=C(C=C1)O)OC |
InChI | InChI=1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19 |
InChIKey | YKPUWZUDDOIDPM-SOFGYWHQSA-N |
Safety Phrases |
Classification: Toxic. May be harmful or fatal if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with shin and eyes Risk Phrases: R25-37/38-41-42/43 Hazard Phrases: H301-H311-H315-H317-H318-H334-H335 Precautionary Phrases: P261-P280-P301 + P310-P305 + P351 + P338-P342 + P311 |
Cite This Product | Capsaicin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-322) |
Alternative Names | (6E)-N-(4-Hydroxy-3-methoxybenzyl)-8-methyl-6-nonenamide, 8-Methyl-N-vanillyl-trans-6-nonenamide |
Research Areas | Ion Channels, Neuroscience, Transient Receptor Potential (TRP) Channels |
PubChem ID | 1548943 |
Scientific Background | Capsaicin is a TRPV1 receptor agonist that activates non-selective cation channels in sensory neurons. It induces the release of substance P and modulates pain signaling pathways. Capsaicin has demonstrated neuroprotective effects in models of cerebral ischemia and is used to study peripheral and central nociceptive mechanisms. Its reversible inhibition of platelet aggregation also suggests vascular implications in neurodegeneration. |
References |
1. Caterina M.J., et al. (1997) Nature. 389(6653): 816-824. 2. Story G.M., Crus-Orengo L. (2007) Am Scientist. 95(4): 326-333. 3. Vaishnava P., Wang D.H. (2003) Curr Med Chem Cadiovasc Hematol Agents. 1(2): 177-188. |
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