Capsaicin

TRPV1opener

Catalog No. SIH-322

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CAS No. 404-86-4
Molecular Formula C18H27NO3
SKU: SIH-322 Categories: ,

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SIH-322_Capsaicin_Chemical_Structure.png
Product Name Capsaicin
Description

TRPV1opener

Purity >60% (HPLC); NMR (conforms)
CAS No. 404-86-4
Molecular Formula C18H27NO3
Molecular Weight 305.41
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Small Molecules
Solubility Soluble in DMSO (20 mg/mL) and ethanol (15 mg/mL)
Source Synthetic
Appearance Off-White Solid
SMILES CC(C)/C=C/CCCCC(=O)NCC1=CC(=C(C=C1)O)OC
InChI InChI=1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19
InChIKey YKPUWZUDDOIDPM-SOFGYWHQSA-N
Safety Phrases Classification: Toxic. May be harmful or fatal if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 - Do not breathe dust
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with shin and eyes
Risk Phrases:
R25-37/38-41-42/43
Hazard Phrases:
H301-H311-H315-H317-H318-H334-H335
Precautionary Phrases:
P261-P280-P301 + P310-P305 + P351 + P338-P342 + P311
Cite This Product Capsaicin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-322)

Biological Description

Alternative Names (6E)-N-(4-Hydroxy-3-methoxybenzyl)-8-methyl-6-nonenamide, 8-Methyl-N-vanillyl-trans-6-nonenamide
Research Areas Ion Channels, Neuroscience, Transient Receptor Potential (TRP) Channels
PubChem ID 1548943
Scientific Background Capsaicin is a TRPV1 receptor agonist that activates non-selective cation channels in sensory neurons. It induces the release of substance P and modulates pain signaling pathways. Capsaicin has demonstrated neuroprotective effects in models of cerebral ischemia and is used to study peripheral and central nociceptive mechanisms. Its reversible inhibition of platelet aggregation also suggests vascular implications in neurodegeneration.
References 1. Caterina M.J., et al. (1997) Nature. 389(6653): 816-824.
2. Story G.M., Crus-Orengo L. (2007) Am Scientist. 95(4): 326-333.
3. Vaishnava P., Wang D.H. (2003) Curr Med Chem Cadiovasc Hematol Agents. 1(2): 177-188.

Product Images

<p>Chemical structure of Capsaicin (SIH-322), a TRPV1opener. CAS #: 404-86-4. Molecular Formula: C18H27NO3. Molecular Weight: 305.41 g/mol.</p>

Chemical structure of Capsaicin (SIH-322), a TRPV1opener. CAS #: 404-86-4. Molecular Formula: C18H27NO3. Molecular Weight: 305.41 g/mol.

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